Evaluating the endophenotype model of ADHD neuropsychological deficit: Results for parents and siblings of children with ADHD combined and inattentive subtypes
Evaluating the endophenotype model of ADHD neuropsychological deficit: Results for parents and siblings of children with ADHD combined and inattentive subtypes
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DOI：
10.1037/0021-843x.113.4.614
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发表时间：
2004-11-01
影响因子：
4.6
通讯作者：
Sachek, J
中科院分区：
文献类型：
--
作者：
Nigg, JT;Blaskey, LG;Sachek, J
神经遗传学模型预测患有注意力缺陷/多动障碍（ADHD）儿童亲属的神经心理缺陷。作者检查了386名亲属（307名父母，79名兄弟姐妹）多动症合并型、多动症不注意型和对照组儿童的执行和监管措施。预测的缺陷出现在跟踪（仅限多动症合并型亲属）、停止信号反应时间（仅限女孩亲属）和反应变异性（仅限母亲）上，但在命名或输出速度上没有。即使亲属的ADHD状态得到控制，效果也普遍存在。ADHD儿童的神经心理受损亚组有明显神经心理缺陷的亲属。作者得出结论，ADHD病因的神经遗传学模型仅支持执行功能的一部分，神经心理学异质性值得对ADHD进行更多的研究。
Neurogenetic models predict neuropsychological weaknesses in the relatives of children with attention-deficit/hyperactivity disorder (ADHD). The authors examined executive and regulatory measures in 386 relatives (307 parents, 79 siblings) of children with ADHD combined type, ADHD inattentive type, and controls. Predicted deficits were seen on trailmaking (relatives of ADHD combined type only), stop-signal reaction times (relatives of girls only), and response variability (mothers only) but not on naming or output speed. Effects generally held, even with relatives' ADHD status controlled. A neuropsychologically impaired subgroup of children with ADHD had relatives with clear neuropsychological weaknesses. The authors conclude that a neurogenetic model of ADHD etiology is supportable only for a subset of executive functions and that neuropsychological heterogeneity warrants more examination in ADHD.