Phospholipase C isozymes as effectors of Ras superfamily GTPases
Phospholipase C isozymes as effectors of Ras superfamily GTPases
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DOI：
10.1194/jlr.r800045-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Sondek, John
中科院分区：
文献类型：
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作者：
Harden, T. Kendall;Hicks, Stephanie N.;Sondek, John
许多细胞外刺激的生理效应是通过受体促进的磷脂酶C激活以及肌醇脂质信号通路启动的。过去认为磷脂酶C促进的信号传导主要通过异源三聚体G蛋白或酪氨酸激酶的激活来实现，但近年来这种观点得到了扩展，因为人们认识到至少三种不同的哺乳动物磷脂酶C同工酶可被GTP酶的Ras超家族成员直接激活。因此，Ras、Rap、Rac和Rho GTP酶都能特异性地调节某些磷脂酶C同工酶，并且对这些信号反应的生理意义的了解也开始逐渐积累。磷脂酶C同工酶的高分辨率三维结构也开始揭示其激活机制。——哈登（Harden, T. K.），希克斯（Hicks, S. N.），松德克（Sondek, J.）。磷脂酶C同工酶作为Ras超家族GTP酶的效应物。《脂质研究杂志》2009年，S243 - S248页。
The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways. The historical view that phospholipase C-promoted signaling primarily occurs through activation of heterotrimeric G proteins or tyrosine kinases has expanded in recent years with the realization that at least three different mammalian phospholipase C isozymes are directly activated by members of the Ras superfamily of GTPases. jlr Thus, Ras, Rap, Rac, and Rho GTPases all specifically regulate certain phospholipase C isozymes, and insight into the physiological significance of these signaling responses is beginning to accrue. High resolution three-dimensional structures of phospholipase C isozymes also are beginning to shed light on their mechanism of activation.-Harden, T. K., S. N. Hicks, and J. Sondek. Phospholipase C isozymes as effectors of Ras superfamily GTPases. J. Lipid Res. 2009. S243-S248.