Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.
Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis.
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DOI：
10.1016/j.nbd.2010.07.013
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发表时间：
2010-12
影响因子：
6.1
通讯作者：
Petersen, Asa
中科院分区：
文献类型：
--
作者：
Soneson, Charlotte;Fontes, Magnus;Zhou, Yongxia;Denisov, Vladimir;Paulsen, Jane S.;Kirik, Deniz;Petersen, Asa
亨廷顿病（HD）是一种由CAG重复扩增引起的致命性神经退行性疾病。它的长度可以用来估计临床诊断的时间，这是由明显的运动症状来定义的。非运动症状在运动发作之前就开始了，涉及下丘脑调节功能的变化，如睡眠、情绪和新陈代谢。因此，我们假设下丘脑的变化在临床诊断之前就已经发生了。在Predict-HD研究中，我们对220名HD基因携带者和75名对照者的横断面MR图像进行了基于体素的形态测量和逻辑回归分析。我们发现，在临床诊断之前，下丘脑区域的变化是可以检测到的，其灰质含量本身就足以区分HD基因携带者和对照病例。总之，我们的研究首次表明，下丘脑区域灰质含量的改变发生在HD临床诊断前至少十年。
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone is sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.
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