HEMATOCRIT AND THE RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY - A 34-YEAR FOLLOW-UP
HEMATOCRIT AND THE RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY - A 34-YEAR FOLLOW-UP
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DOI：
10.1016/0002-8703(94)90679-3
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发表时间：
1994-03-01
影响因子：
4.8
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
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作者：
GAGNON, DR;ZHANG, TJ;KANNEL, WB
我们对 Framingham 队列中的 5209 名男性和女性进行了 34 年的随访，研究了 CVD 死亡率和发病率风险与 HCT 之间的关系。 HCT 值位于最高五分位数的受试者中，全因死亡以及 CVD 导致的发病率和死亡率的风险增加。没有证据表明 HCT 值低于中位值的男性的 CVD 风险会降低，而 HCT 值较低的女性实际上表现出 CVD 事件的风险增加，这表明 HCT 和 CVD 事件之间存在 J 形或 U 形关系。 HCT 对 CVD 事件的影响似乎因年龄组和性别而异。 HCT 与 CVD 的发生率显着相关，包括年轻男性的 CHD、MI、心绞痛、中风和 IC。在年轻女性中，HCT 与 CVD、CHD、MI 的发生率以及 CVD 和 CHD 的死亡率相关。在老年女性中，CHF 发病率和中风死亡呈负相关。这些结果支持这样的假设：HCT 是某些 CVD 事件的重要危险因素，这种关联值得进一步研究。
We examined the relationship between the risk of CVD mortality and morbidity and HCT over a period of 34 years of follow-up in the 5209 men and women in the Framingham cohort. There was an increased risk of all-cause death as well as morbidity and mortality due to CVD in subjects with HCT values in the highest quintile. There was no evidence of a decreased risk of CVD in men with lower than median HCT values, and women actually showed increased risk of CVD events with lower HCT values, indicating a J- or U-shaped relationship between HCT and CVD events. The impact of HCT on CVD events appears to differ for different age groups and by sex. HCT is significantly related to the incidence of CVD, including CHD, MI, angina pectoris, stroke, and IC in younger men. In younger women, HCT is related to the incidence of CVD, CHD, MI, and mortality from CVD and CHD. A negative association with CHF incidence and stroke death is noted in elderly women. These results support the hypothesis that HCT is an important risk factor for some CVD events, an association that merits further investigation.