Using real-time fMRI to learn voluntary regulation of the anterior insula in the presence of threat-related stimuli
Using real-time fMRI to learn voluntary regulation of the anterior insula in the presence of threat-related stimuli
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DOI：
10.1093/scan/nsr061
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发表时间：
2012-08-01
影响因子：
4.2
通讯作者：
Birbaumer, Niels
中科院分区：
文献类型：
--
作者：
Veit, Ralf;Singh, Vanessa;Birbaumer, Niels
以前的研究表明，健康的参与者通过使用实时功能性磁共振成像（rt-fMRI）的操作训练来学习控制局部大脑活动。然而，在基于rt-fMRI的训练过程中，关于关键脑区之间相互作用的动态数据很少。在这里，我们研究了自我调节的刺激引起的神经元激活，并进行了心理生理相互作用（PPI）的实时自我调节数据的分析。在自愿上调的左前额叶在存在的威胁相关的图片，差异激活观察到在腹外侧前额叶皮层，额盖，中扣带皮层和右额叶。与无调节相比，下调揭示了右上级颞叶皮层、右下顶叶皮层和右中额叶皮层的额外激活。有一个显着的学习效果，在会议期间上调，记录了一个显着改善前额叶控制随着时间的推移。连通性分析显示，左前额叶活动的成功上调，而观看令人厌恶的图片直接调制的背内侧和腹外侧前额叶皮层。活动的下调更难以实现，并且没有观察到学习效果。更广泛的培训可能是必要的成功下调。这些发现说明了在存在威胁相关刺激的情况下，前额叶活动调节过程中不同脑区之间的功能相互作用。
Previous studies have shown that healthy participants learn to control local brain activity with operant training by using real-time functional magnetic resonance imaging (rt-fMRI). Very little data exist, however, on the dynamics of interaction between critical brain regions during rt-fMRI-based training. Here, we examined self-regulation of stimulus-elicited insula activation and performed a psychophysiological interaction (PPI) analysis of real-time self-regulation data. During voluntary up-regulation of the left anterior insula in the presence of threat-related pictures, differential activations were observed in the ventrolateral prefrontal cortex, the frontal operculum, the middle cingulate cortex and the right insula. Down-regulation in comparison to no-regulation revealed additional activations in right superior temporal cortex, right inferior parietal cortex and right middle frontal cortex. There was a significant learning effect over sessions during up-regulation, documented by a significant improvement of anterior insula control over time. Connectivity analysis revealed that successful up-regulation of the activity in left anterior insula while viewing aversive pictures was directly modulated by dorsomedial and ventrolateral prefrontal cortex. Down-regulation of activity was more difficult to achieve and no learning effect was observed. More extensive training might be necessary for successful down-regulation. These findings illustrate the functional interactions between different brain areas during regulation of anterior insula activity in the presence of threat-related stimuli.