Respiratory interneurons of the lower cervical (C4-C5) cord: membrane potential changes during fictive coughing, vomiting, and swallowing in the decerebrate cat.
Respiratory interneurons of the lower cervical (C4-C5) cord: membrane potential changes during fictive coughing, vomiting, and swallowing in the decerebrate cat.
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下颈（C4-C5）脊髓的呼吸中间神经元：去大脑猫在虚构的咳嗽、呕吐和吞咽过程中膜电位的变化。
DOI：
10.1007/bf00374181
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Miller,AD
中科院分区：
文献类型：
--
作者：
Grélot,L;Milano,S;Portillo,F;Miller,AD
在C4-C5颈髓中间神经元在不同的行为模式中传递中央驱动器到膈运动神经元的可能作用进行了研究，使用细胞内记录在去大脑，麻痹，人工通气猫。11个细胞被暂时归类为呼吸中间神经元，因为它们：（i）不能从同侧整个胸内膈神经逆向激活，以及（ii）在正常呼吸（7.3 mV ± 3.6，范围2 - 13.5 mV）或非呼吸行为模式期间表现出较大的膜电位变化。6个神经元在膈神经放电的阶段去极化，其他4个在呼气相去极化，一个神经元在呼气和吸气结束时表现出去极化。在虚构的咳嗽、呕吐和吞咽过程中观察到各种反应。这一结果与C4-C5呼气中间神经元在不同的行为模式下传递对膈运动神经元的抑制是一致的。吸气和多相神经元的反应表明，这些中间神经元的作用是复杂的模式，而不是简单地中继中枢兴奋或抑制驱动膈运动神经元。
The possible roles of interneurons in the C4-C5 cervical spinal cord in conveying central drives to phrenic motoneurons during different behaviour patterns were investigated using intracellular recordings in decerebrate, paralysed, artificially ventilated cats. Eleven cells were tentatively classified as respiratory interneurons since they: (i) could not be antidromically activated from the ipsilateral whole intrathoracic phrenic nerve, and (ii) exhibited large membrane potential changes during eupnea (7.3 mV±3.6, range 2–13.5 mV) or non-respiratory behaviour patterns. Six neurons depolarized in phase with phrenic discharge; four others depolarized during the expiratory phase; one neuron exhibited depolarization during the end of both expiration and inspiration. A variety of responses was observed during fictive coughing, vomiting, and swallowing. The results are consistent with C4-C5 expiratory interneurons conveying inhibition to phrenic motoneurons during different behaviour patterns. The responses of inspiratory and multiphasic neurons suggest that the roles of these interneurons are mode complex than simply relaying central excitatory or inhibitory drive to phrenic motoneurons.