Evolutionary analyses of ABC transporters of Dictyostelium discoideum
Evolutionary analyses of ABC transporters of Dictyostelium discoideum
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DOI：
10.1128/ec.1.4.643-652.2002
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发表时间：
2002-08-01
期刊：
影响因子：
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通讯作者：
Loomis, WF
中科院分区：
文献类型：
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作者：
Anjard, C;Loomis, WF
ABC超家族基因是细菌和真核生物基因组中最大的家族之一。这些基因编码的蛋白质都带有一个特有的200-250个氨基酸的ATP结合盒，这让它们有了自己的姓氏。在细菌中，它们主要参与营养输入，而在真核生物中，许多参与输出。根据序列同源性、结构域拓扑和功能，在真核生物中已经定义了七个不同的家族。虽然之前只有6个ABC基因在盘基网柄菌中得到了详细的研究，但从先进的盘基网柄菌基因组计划中获得的序列已经使我们能够识别这个超家族的68个成员。为了深入了解这个超级家族的进化，我们对它们进行了分类，并与动物、植物和真菌的同源基因进行了比较。看来，许多推测存在于树冠生物体祖先中的基因在一些但不是所有的门中广泛复制，而另一些基因则在一个或另一个谱系中丢失。
The ABC superfamily of genes is one of the largest in the genomes of both bacteria and eukaryotes. The proteins encoded by these genes all carry a characteristic 200- to 250-amino-acid ATP-binding cassette that gives them their family name. In bacteria they are mostly involved in nutrient import, while in eukaryotes many are involved in export. Seven different families have been defined in eukaryotes based on sequence homology, domain topology, and function. While only 6 ABC genes in Dictyostelium discoideum have been studied in detail previously, sequences from the well-advanced Dictyostelium genome project have allowed us to recognize 68 members of this superfamily. They have been classified and compared to animal, plant, and fungal orthologs in order to gain some insight into the evolution of this superfamily. It appears that many of the genes inferred to have been present in the ancestor of the crown organisms duplicated extensively in some but not all phyla, while others were lost in one lineage or the other.