Calculation of cross-sectional geometry of bone from CT images with application in postmenopausal women.
Calculation of cross-sectional geometry of bone from CT images with application in postmenopausal women.
复制标题
根据 CT 图像计算骨的横截面几何形状并应用于绝经后妇女。
DOI：
10.1097/00004728-199407000-00021
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发表时间：
1994
影响因子：
1.3
通讯作者：
Hayes,WC
中科院分区：
文献类型：
--
作者：
Corcoran,TA;Sandler,RB;Myers,ER;Lebowitz,HH;Hayes,WC
目的：本研究的目的是开发一个软件程序，计算骨横截面积（CSA）和数字图像的惯性矩，测试计算的准确性，并实施软件在一个大的绝经后women.Materials和方法组的骨性质的纵向变化的研究：一个程序称为SLICE被改编为使用计算机断层扫描（CT）骨图像作为输入。结果程序SLICE_CT的主要结果变量为骨CSA、面积惯性矩和质量加权惯性矩。使用近似皮质骨横截面的代表性CT编号阵列测试SLICE_CT的准确性。然后，该技术被应用于图像从3年的纵向研究的半径在86绝经后妇女进行定量CT的优势半径在30%的距离从手腕到手肘。受试者入组研究时的平均年龄为57岁。对基线和3年时的图像进行分析，并通过配对差异双尾t检验检验横截面几何形状无变化的零假设。结果：在适当分割的情况下，以半最大高度为阈值，SLICE_CT的误差< 1%。在绝经后妇女的纵向研究中，桡骨CSA的平均变化为-1.4%（SD= 3.0%; p< 0.001）。结论：SLICE_CT是一种准确的测量数字图像横断面几何形状的方法，可用于检测绝经后妇女桡骨横断面几何形状随年龄的变化。结果表明，桡骨重塑以补偿与老化相关的骨丢失和骨的材料性能降低。
Objective: The objectives of this study were to develop a software program that calculates bone cross-sectional area (CSA) and moments of inertia from digital images, test the computations for accuracy, and implement the software in a study of longitudinal changes in bone properties in a large group of postmenopausal women.Materials and Methods: A program called SLICE was adapted to use computed tomography (CT) bone images as input. The main outcome variables of the resulting program, SLICE_CT, were bone CSA, areal moments of inertia, and mass-weighted moments of inertia. SLICE_CT was tested for accuracy using representative arrays of CT numbers that approximate cross-sections of cortical bone. Then the technique was applied to images from a 3 year longitudinal study of the radius in 86 postmenopausal women who underwent quantitative CT of the dominant radius at 30% the distance from the wrist to the elbow. The mean age of the subjects at entry into the study was 57 years. Images at baseline and at 3 years were analyzed, and the null hypothesis of no change in cross-sectional geometry was tested by a paired difference two-tailed t test.Results: The error of SLICE_CT was< 1% with proper segmentation, using half-maximal height as the threshold. In the longitudinal study of postmenopausal women, the mean change of CSA of the radius was-1.4%(SD= 3.0%; p< 0.001). However, there was a compensatory 2.4% increase in the cross-sectional second polar moment of inertia (SD= 3.7%; p< 0.001).Conclusion: SLICE_CT is an accurate method with which to determine cross-sectional geometry of digital images and can be used to detect changes in cross-sectional geometry of the radius with age in postmenopausal women. The results indicate that the radius remodels to compensate for bone loss and decreasing material properties of bone associated with aging.