BLOOD-PRESSURE AND HEART-RATE REGULATING CAPACITY OF CAROTID-SINUS DURING CHANGES IN BLOOD-VOLUME DISTRIBUTION IN MAN
BLOOD-PRESSURE AND HEART-RATE REGULATING CAPACITY OF CAROTID-SINUS DURING CHANGES IN BLOOD-VOLUME DISTRIBUTION IN MAN
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DOI：
10.1111/j.1748-1716.1977.tb10383.x
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
TRANESJO, J
中科院分区：
文献类型：
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作者：
BEVEGARD, S;CASTENFORS, J;TRANESJO, J
在18名受试者中研究了血容量分布变化对颈动脉压力反射的影响。通过改变下半身周围高于和低于环境的压力来改变血容量分布，从而改变该区域中汇集的血液量并对中心血容量施加次要影响。通过改变封闭颈部的气密盒中的压力来刺激颈动脉牵张感受器。为了获得标准化的颈动脉窦刺激（SCS），箱中的压力以0.03Hz的固定频率在-10和-40mmHg之间正弦地变化。通过在数字计算机上离线进行谐波分析来评估对心率和血压的影响。在下体负压为-40 mmHg（LBNP -40）期间，即，在已知的减少中心血容量的过程中，SCS引起对血压调节能力的增强效应，但对心率反应没有增强效应。将血压调节能力表示为收缩期动脉压的峰-峰变化，在LBNP-40 mmHg期间的响应几乎是对照值的两倍。相反的刺激（下半身的正压力）影响SCS诱导的效果只有轻微的，但平均而言，血压和心率调节能力的轻微减少被发现与控制条件相比，虽然差异没有达到显着的水平。血容量分布的变化可能通过对中心血容量和/或中心静脉压变化敏感的胸内受体改变颈动脉压力感受器反射的功能。
The influence of changes in blood volume distribution on the carotid baroreflex was studied in 18 subjects. Blood volume distribution was changed by varying the pressure around the lower body above and below ambient, thereby varying the amount of blood pooled in this region and exerting a secondary influence on the central blood volume. The carotid arterial stretch receptors were stimulated by varying the pressure in an air-tight box enclosing the neck. To obtain a standardized carotid sinus stimulus (SCS) the pressure in the box was varied sinusoidally between -10 and -40 mmHg with a fixed frequency of 0.03 Hz. The effects on heart rate and blood pressure were assessed by harmonic analysis performed off-line on a digital computer. During lower body negative pressure of -40 mmHg (LBNP -40), i.e., during a procedure known to reduce the central blood volume, SCS induced an augmented effect on the blood pressure regulating capacity but not on the heart rate response. Expressing the blood pressure regulating capacity as peak-to-peak changes in systolic arterial pressure, the response during LBNP -40 mmHg was almost twice the control value. The opposite stimulus (lower body positive pressure) influenced the SCS-induced effects only slightly but on the average a minor reduction in both blood pressure and heart rate regulating capacity was found compared with the control condition, though the difference did not reach significant levels. Changes in blood volume distribution modify the function of the carotid baroreflex, possibly via intrathoracic receptors sensitive to changes in central blood volume and/or central venous pressure.