DOSE-RESPONSE EFFECTS OF ETHANOL ON THE SLEEP OF YOUNG MEN
DOSE-RESPONSE EFFECTS OF ETHANOL ON THE SLEEP OF YOUNG MEN
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DOI：
10.15288/jsa.1982.43.434
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
CAIRNS, J
中科院分区：
文献类型：
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作者：
MACLEAN, AW;CAIRNS, J
对10名健康青年男性进行了中等剂量酒精与睡眠之间的剂量-反应关系的研究，其中电极安装在标准睡眠记录上。在一个适应之夜之后，受试者被观察了5次，每次之间至少有5个晚上。受试者饮用含0.00g、0.25g、0.50g、0.75g或1.00g 95%乙醇的饮料，产生的平均血液酒精浓度分别为0.000、0.008、0.049和0.074 mg/100ml。虽然快速眼动睡眠(REM)的绝对量与剂量之间没有明显的关系，但在睡眠的前5h，快速眼动(REM)的相积累量呈线性下降。睡眠前3h慢波(3、4期)睡眠随剂量增加而延长，入睡潜伏期缩短，两者呈线性关系。有一些证据表明，在夜间后半段存在剂量依赖性的反弹效应，并且在高剂量水平下干扰增加。
The dose-response relationship between moderate doses of alcohol and human sleep was studied in 10 healthy young men with electrodes attached for standard sleep recording. Following 1 adaptation night, subjects were seen on 5 occasions with a minimum of 5 nights between each occasion. Subjects consumed a beverage containing either 0.00, 0.25, 0.50, 0.75 or 1.00 g of 95% ethanol/kg body wt producing mean blood alcohol concentrations of 0.000, 0.008, 0.049 and 0.074 mg/100 ml, respectively. Although there was no significant relationship between the absolute amount of rapid eye movement (REM) sleep and dose, there was a linear decline in the amount of phasic REM accumulated in the first 5 h of sleep. Slow wave (stages 3 and 4) sleep in the first 3 h of sleep increased with dose and the latency of sleep onset declined, both effects being linear. There was some evidence of dose-dependent rebound effects in the latter part of the night and of increased disturbance at the high dose level.