Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)
Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)
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DOI：
10.1007/s10329-013-0397-8
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发表时间：
2014-04-01
期刊：
影响因子：
1.7
通讯作者：
Hau, J.
中科院分区：
文献类型：
--
作者：
Darusman, H. S.;Call, J.;Hau, J.
我们使用三种非人类灵长类动物的记忆测试来比较年轻、中年和老年食蟹猴的延迟反应任务表现。对18只食蟹猴进行了试验，其中幼年6只（4-9岁），中年6只（10-19岁），老年6只（20岁以上）。总的来说，老年猴子的得分明显低于其他两个年龄组的猴子。较长的刺激呈现和反应之间的延迟增加了年老猴子和年轻猴子之间的表现差异。年老的猴子尤其表现出视觉空间记忆受损、记忆巩固和执行功能恶化的迹象。这些结果增加了支持Macaca fascularis在认知研究中的效用的证据，并作为与年龄相关的记忆障碍/痴呆相关疾病的潜在转化模型。
We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuospatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.