EPIDERMAL GROWTH-FACTOR REPLACES ESTROGEN IN THE STIMULATION OF FEMALE GENITAL-TRACT GROWTH AND DIFFERENTIATION
EPIDERMAL GROWTH-FACTOR REPLACES ESTROGEN IN THE STIMULATION OF FEMALE GENITAL-TRACT GROWTH AND DIFFERENTIATION
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DOI：
10.1073/pnas.88.1.21
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发表时间：
1991-01-01
影响因子：
11.1
通讯作者：
MCLACHLAN, JA
中科院分区：
文献类型：
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作者：
NELSON, KG;TAKAHASHI, T;MCLACHLAN, JA
在这里提出的体内研究表明，表皮生长因子（EGF）是一个重要的自分泌和/或旁分泌调解员雌激素诱导的生长和分化在小鼠子宫和阴道。EGF特异性抗体显著抑制雌激素诱导的子宫和阴道生长，从而暗示EGF参与雌激素作用。 此外，EGF通过缓释丸在卵巢切除小鼠中作为一种有效的子宫和阴道有丝分裂原以及阴道角化的诱导剂。 用卵巢切除、肾上腺切除、垂体切除的小鼠进行的实验表明，EGF促有丝分裂不需要垂体或肾上腺激素。EGF治疗也模仿雌激素诱导子宫乳铁蛋白（一种主要的雌激素诱导分泌蛋白）mRNA和蛋白质。 这些数据表明，EGF具有雌激素样作用，促进生殖道细胞生长，EGF可能是体内雌激素作用的重要介质。
The in vivo studies presented here demonstrate that epidermal growth factor (EGF) is an important autocrine and/or paracrine mediator of estrogen-induced growth and differentiation in mouse uterus and vagina. An antibody specific for EGF significantly inhibited estrogen-induced uterine and vaginal growth, thereby implicating EGF involvement in estrogen action. Furthermore, EGF administered via slow-release pellets in ovariectomized mice acted as a potent uterine and vaginal mitogen as well as inducer of vaginal keratinization. Experiments with ovariectomized, adrenalectomized, hypophysectomized mice indicated that EGF mitogenesis does not require pituitary or adrenal hormones. Treatment with EGF also mimicked estrogen in the induction of uterine lactoferrin (a major estrogen-inducible secretory protein) mRNA and protein. These data suggest that EGF has estrogen-like effects in the promotion of cell growth in the reproductive tract and that EGF may serve as an important mediator of estrogen action in vivo.