Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans
Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans
复制标题
DOI：
10.1038/nn.2854
复制
发表时间：
2011-08-01
影响因子：
25
通讯作者：
Mori, Ikue
中科院分区：
文献类型：
--
作者：
Sugi, Takuma;Nishida, Yukuo;Mori, Ikue
动物通过改变行为策略来应对环境变化。环境信息通常由产生行为的神经回路中的感觉神经元接收。然而，尽管环境温度不可避免地会影响动物的全身，但系统温度感知的机制在很大程度上仍然不清楚。我们在这里展示了系统的温度信号诱导线虫基于记忆的行为的改变。在行为条件作用过程中，非神经元细胞以及神经元细胞通过热休克转录因子对培养温度做出反应，该转录因子驱动新发现的基因表达动态。这种全身性温度信号通过雌激素信号通路非细胞自主地调节热敏神经元，产生趋热行为。我们提供了神经系统中的系统环境识别和行为可塑性之间的联系。
Animals cope with environmental changes by altering behavioral strategy. Environmental information is generally received by sensory neurons in the neural circuit that generates behavior. However, although environmental temperature inevitably influences an animal's entire body, the mechanism of systemic temperature perception remains largely unknown. We show here that systemic temperature signaling induces a change in a memory-based behavior in C. elegans. During behavioral conditioning, non-neuronal cells as well as neuronal cells respond to cultivation temperature through a heat-shock transcription factor that drives newly identified gene expression dynamics. This systemic temperature signaling regulates thermosensory neurons non-cell-autonomously through the estrogen signaling pathway, producing thermotactic behavior. We provide a link between systemic environmental recognition and behavioral plasticity in the nervous system.