DIIODO-L-TYROSINE-LABELED DEXTRANS AS MOLECULAR-SIZE MARKERS OF NASAL ABSORPTION IN THE RAT
DIIODO-L-TYROSINE-LABELED DEXTRANS AS MOLECULAR-SIZE MARKERS OF NASAL ABSORPTION IN THE RAT
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DOI：
10.1111/j.2042-7158.1992.tb05462.x
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发表时间：
1992-07-01
影响因子：
3.3
通讯作者：
SCHACHT, EH
中科院分区：
文献类型：
--
作者：
FISHER, AN;ILLUM, L;SCHACHT, EH
一系列分级的二碘-L-酪氨酸标记的葡聚糖（DIT葡聚糖），具有一个狭窄的范围内的数均分子量从1260至45 500 Da，鼻内和静脉内给药麻醉大鼠。这些化合物的鼻吸收范围为0.6 - 52.7%。分子大小与鼻内吸收剂量的比例呈反比关系。该研究证明了DIT葡聚糖作为分子量标记物的有用性，并证实了分子大小与高度水溶性化合物的鼻吸收之间的关系。这些结果也支持了在鼻粘膜中存在连续范围的水孔的主张。
A series of fractionated di-iodo-L-tyrosine-labelled dextrans (DIT dextrans), with a narrow range of number average molecular weights from 1260 to 45 500 Da, was administered intranasally and intravenously to anaesthetized rats. The nasal absorption of these compounds ranged from 0.6 to 52.7%. There was an inverse relationship between molecular size and the proportion of an intranasal dose absorbed. The study demonstrated the usefulness of DIT dextrans as molecular weight markers and confirmed the relationship between molecular size and nasal absorption for highly water soluble compounds. These results also supported the proposition that there is a continuous range of aqueous pores in the nasal mucosa.