Lesion HLA-F expression is irrelevant to prognosis for patients with gastric cancer
Lesion HLA-F expression is irrelevant to prognosis for patients with gastric cancer
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病灶HLA-F表达与胃癌患者预后无关
DOI：
10.1016/j.humimm.2013.03.002
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发表时间：
2013-07-01
期刊：
影响因子：
2.7
通讯作者：
Yan, Wei-Hua
中科院分区：
文献类型：
--
作者：
Zhang, Jian-Gang;Zhang, Xia;Yan, Wei-Hua
人类白细胞抗原（HLA）抗原表达的改变被认为在恶性肿瘤的进展中发挥着关键作用。然而，非经典 HLA I 类抗原 HLA-F 的临床意义仍然很大程度上未知。在本研究中，通过免疫组织化学分析了 277 个原发性胃癌 (GC) 病灶中 HLA-F 的表达。数据显示，71.1%（197/277）的GC病变中观察到HLA-F表达。病灶HLA-F表达与性别、年龄、肿瘤浸润深度、疾病分期等临床参数无关。生存分析显示，GC 病变中 HLA-F 的表达与患者预后无关（p = 0.190）。病变HLA-F阴性和阳性患者的平均总生存时间（MOS）分别为11.3个月（95% CI：9.3-13.3）和13.9个月（95% CI：10.5-17.3）。总之，我们的研究提供了 HLA-F 表达与胃癌患者预后无关的证据。 (c) 2013 年美国组织相容性和免疫遗传学学会。由爱思唯尔公司出版。保留所有权利。
Alteration of human leukocyte antigen (HLA) antigen expression has been supposed to play critical roles in progression of malignancies. However, clinical significance of the non-classical HLA class I antigen HLA-F remains largely unknown. In this study, HLA-F expression in 277 primary gastric cancer (GC) lesions was analyzed by immunohistochemistry. Data revealed that HLA-F expression was observed in 71.1% (197/277) of the GC lesions. Lesion HLA-F expression was unrelated to the clinicoparameters such as gender, age, depth of tumor invasion and disease stage. Survival analysis revealed that HLA-F expression in GC lesion was unrelated to patient prognosis (p = 0.190). The mean overall survival time (MOS) for lesion HLA-F negative and positive patients was 11.3 months (95% CI: 9.3-13.3) and 13.9 months (95% CI: 10.5-17.3), respectively. In conclusion, our study provided the evidence that HLA-F expression was unrelated to prognosis for patients with gastric cancer. (c) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.