Efficiency of photodynamic therapy in the treatment of peri-implantitis - A three-month randomized controlled clinical trial
Efficiency of photodynamic therapy in the treatment of peri-implantitis - A three-month randomized controlled clinical trial
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DOI：
10.2298/sarh1610478r
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发表时间：
2016-09-01
影响因子：
0.2
通讯作者：
Aleksic, Zoran
中科院分区：
文献类型：
--
作者：
Rakasevic, Dragana;Lazic, Zoran;Aleksic, Zoran
种植体周围炎是一种种植体周围组织的炎性病变。根除致病菌和去除种植体表面的污染对于获得可预测和稳定的临床结果至关重要。光动力疗法（PDT）是手术治疗细菌感染的一种非侵入性辅助治疗方法。目的评价植周炎手术后辅助PDT治疗的早期临床和微生物学结果。方法52例诊断为种植体周围炎的患者分为两组。研究组采用PDT对种植体表面进行净化；对照组采用洗必泰凝胶（CHX）加生理盐水冲洗。在治疗前（基线值）和手术治疗后3个月记录几个临床参数。在治疗前、手术治疗期间（种植体表面去污前后）和手术后3个月采集微生物鉴定样本，用生化分析鉴定系统进行分析。结果与CHX相比，PDT的使用显著减少了探查出血（p < 0.001）。结果显示，手术后立即和三个月后，种植体表面明显去污，厌氧菌完全消除。结论PDT在治疗种植体周围炎中可作为手术的辅助治疗，对种植体表面及周围组织进行净化。
Introduction Peri-implantitis is an inflammatory lesion of peri-implant tissues. Eradication of the causative bacteria and decontamination of the implant surface is essential in achieving predictable and stabile clinical results. Photodynamic therapy (PDT) is non-invasive adjuvant therapeutic method to surgery in the treatment of bacterial infection.Objective The aim of this study was to evaluate early clinical and microbiological outcomes of periimplantitis after surgical therapy with adjuvant PDT.Methods Fifty-two diagnosed peri-implantitis sites were divided into two groups. PDT was used for decontamination of implant surface in the study group; in the control group, chlorhexidine gel (CHX) followed by saline irrigation was applied. Several clinical parameters were recorded before the treatment (baseline values) and three months after surgical treatment. Samples for microbiological identification were collected before therapy, during the surgical therapy (before and after decontamination of implant surface), and three months thereafter, and analyzed with identification systems using biochemical analysis. Results The use of PDT resulted in significant decrease of bleeding on probing in comparison to CHX (p < 0.001). It showed significant decontamination of implant surfaces with complete elimination of anaerobic bacteria immediately after surgical procedure and three months later.Conclusion The results indicate that PDT can be used as an adjuvant therapy to surgery for decontamination of implant surface and surrounding peri-implant tissues within the treatment of peri-implantitis.