HIGH-LEVELS OF IGM ANTIBODIES SPECIFIC FOR TOXOPLASMA-GONDII IN PREGNANCY 12 YEARS AFTER PRIMARY TOXOPLASMA INFECTION - CASE-REPORT
HIGH-LEVELS OF IGM ANTIBODIES SPECIFIC FOR TOXOPLASMA-GONDII IN PREGNANCY 12 YEARS AFTER PRIMARY TOXOPLASMA INFECTION - CASE-REPORT
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DOI：
10.1159/000293151
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发表时间：
1991-01-01
影响因子：
2.1
通讯作者：
DJURKOVICDJAKOVIC, O
中科院分区：
文献类型：
--
作者：
BOBIC, B;SIBALIC, D;DJURKOVICDJAKOVIC, O
本文报告一例弓形虫病孕妇经免疫吸附凝集试验（ISAgA）检测出高水平特异性IgM抗体的病例。 患者在妊娠前12年通过Sabin-Feldman试验（SFT）检测到的特异性抗体滴度增加和病理组织学检查诊断为急性淋巴结弓形虫病。 在妊娠期间，她通过SFT、酶联免疫吸附试验（ELISA）、间接荧光抗体试验（IFAT）、间接血凝试验（IHAT）和直接凝集试验登记的特异性抗体滴度稳定。 用ISAgA检测特异性IgM抗体，而用IgM-IFAT、IgM-ELISA和IgM-IHAT均检测不到。 她有一个正常的怀孕和生下一个临床健康的婴儿谁有一个负ISAGA发现在7天的年龄。 该病例表明ISAgA不一定是近期感染的标志物，因此对妊娠期弓形虫病的诊断不可靠。
A case of high levels of specific IgM antibodies registered by the immunosorbent agglutination assay (ISAgA) in a pregnant woman with a history of toxoplasmosis is reported. The patient had acute lymphoglandular toxoplasmosis diagnosed serologically by increases in the specific antibody titer detected by the Sabin-Feldman test (SFT) and pathohistologically 12 years before pregnancy. In pregnancy, she had stable titers of specific antibodies registered by the SFT, enzyme-linked immunosorbent assay (ELISA), indirect fluorescent antibody test (IFAT), indirect hemagglutination test (IHAT) and direct agglutination test. Specific IgM antibodies were detected by the ISAgA but not by the IgM-IFAT, IgM-ELISA and IgM-IHAT. She had a normal pregnancy and gave birth to a clinically healthy baby who had a negative ISAgA finding at 7 days of age. This case indicates that ISAgA is not necessarily a marker of recent infection and is therefore not reliable for the diagnosis of toxoplasmosis in pregnancy.