Impact of community-based integrated mass drug administration on schistosomiasis and soil-transmitted helminth prevalence in Togo
Impact of community-based integrated mass drug administration on schistosomiasis and soil-transmitted helminth prevalence in Togo
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DOI：
10.1371/journal.pntd.0006551
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发表时间：
2018-08-01
影响因子：
3.8
通讯作者：
Sognikin, Koffi S.
中科院分区：
文献类型：
--
作者：
Bronzan, Rachel N.;Dorkenoo, Ameyo M.;Sognikin, Koffi S.
自2010年以来，多哥每年都开展以社区为基础的综合性大规模药物管理，以防治土传蠕虫和血吸虫病。治疗频率和目标人群是根据2007年和2009年基线调查测量的疾病流行率以及世卫组织准则确定的。报告的方案治疗覆盖率平均超过94%。多哥在2015年进行了一项横断面调查，以评估4至5年的MDA对这些疾病的影响。方法/主要发现在首都以外的每个分区，访问了基线时的相同学校，并抽取了15名6至9岁儿童的样本。每个孩子都提交了尿液和粪便样本。通过试纸检测尿液样本中是否存在血液，作为埃及血吸虫感染的替代指标。粪便样本进行了分析的加藤-Katz方法STH和曼氏血吸虫。在基线时，17，100名儿童在562个分区的1，129所学校入学; 2015年，16，890名儿童在同一所学校入学。STH和血吸虫病的总患病率均显著下降，STH从31.5%降至11.6%，血吸虫病从23.5%降至5.0%（p
BackgroundTogo has conducted annual, integrated, community-based mass drug administration (MDA) for soil-transmitted helminths (STH) and schistosomiasis since 2010. Treatment frequency and target populations are determined by disease prevalence, as measured by baseline surveys in 2007 and 2009, and WHO guidelines. Reported programmatic treatment coverage has averaged over 94%. Togo conducted a cross-sectional survey in 2015 to assess the impact of four to five years of MDA on these diseases.Methodology/Principal findingsIn every sub-district in the country outside the capital, the same schools were visited as at baseline and a sample of fifteen children age 6 to 9 years old was drawn. Each child submitted urine and a stool sample. Urine samples were tested by dipstick for the presence of blood as a proxy measure of Schistosoma haematobium infection. Stool samples were analyzed by the Kato-Katz method for STH and Schistosoma mansoni. At baseline, 17,100 children were enrolled at 1,129 schools in 562 sub-districts; in 2015, 16,890 children were enrolled at the same schools. The overall prevalence of both STH and schistosomiasis declined significantly, from 31.5% to 11.6% for STH and from 23.5% to 5.0% for schistosomiasis (p