Hypothyroidism prolongs mitotic activity in the post-natal mouse brain
Hypothyroidism prolongs mitotic activity in the post-natal mouse brain
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DOI：
10.1016/s0304-3940(00)00768-0
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发表时间：
2000-02-18
影响因子：
2.5
通讯作者：
Demeneix, B
中科院分区：
文献类型：
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作者：
Hadj-Sahraoui, N;Seugnet, I;Demeneix, B
在小鼠出生后的前三周测量了循环T-4和T-3，发现它们以三相的方式增加。第一次增加发生在出生后第6天，同时显示出出生后有丝分裂的区域的溴脱氧尿嘧啶核苷掺入减少。我们调查了甲状腺激素水平升高和增殖减少之间是否存在因果关系，这种关系是通过诱导DARN和子代的甲状腺功能减退来实现的。甲状腺功能减退症延长了嗅球、海马体、室下区和小脑皮质的有丝分裂活动。这表明，T-3在出生后第一周结束时的增加与终止小鼠大脑许多部分的祖细胞增殖有关。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
Circulating T-4 and T-3 were measured during the first three post-natal weeks in the mouse and found to increase in a triphasic manner. The first increase occurred at post-natal day 6 and was simultaneous with a decrease in bromodeoxyuridine incorporation in areas showing post-natal mitosis. We investigated whether there was a causal relationship between increased thyroid hormone levels and decreased proliferation by inducing hypothyroidism in darns and progeny. Hypothyroidism prolonged mitotic activity in the olfactory bulb, hippocampus, subventricular zone and the cerebellar cortex. This suggests that the increase in T-3 at the end of the first postnatal week is implicated in terminating progenitor proliferation in many parts of the mouse brain. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.