Comparison of myocardial catecholamine balance in chronic congestive heart failure and in angina pectoris without failure.
Comparison of myocardial catecholamine balance in chronic congestive heart failure and in angina pectoris without failure.
复制标题
慢性充血性心力衰竭和无衰竭心绞痛心肌儿茶酚胺平衡的比较。
DOI：
10.1016/s0002-9149(84)80208-8
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Kanu Chatterjee
中科院分区：
文献类型：
--
作者：
Karl Swedberg;C. Viquerat;Jean;M. F. Roizen;Beverley Atherton;W. W. Parmley;Kanu Chatterjee
为了评价心衰时心肌儿茶酚胺平衡，测定了30例慢性左心室衰竭（CHF）患者和25例无心衰的心绞痛（AP）患者的全身血流动力学、冠状窦血流量、动脉和冠状窦静脉去甲肾上腺素（NE）和肾上腺素(E)浓度。CHF组脑卒中工作指数较低（CHF 20±9,AP 53±13 g-m/m2, p <0.001），肺毛细血管楔压较高（CHF 28±8,AP 11±4 mm Hg, p <0.001），提示左室功能下降。两组冠状动脉窦血流量相似（CHF 97±70,AP 73±32 ml/min，差异无统计学意义）。CHF组动脉NE浓度（634±582 pg/ml）和冠状窦静脉NE浓度（1038±1014 pg/ml）显著高于AP组（动脉NE浓度185±135 pg/ml，冠状窦NE浓度231±167 pg/ml， p <0.001）。CHF患者净心肌NE释放量约为AP患者的20倍（CHF 38,548±48,622,AP 2,245±10,242 pg/min, p <0.001）。两组动脉E和心肌E摄取相似。尽管心肌净NE释放增加的机制尚不清楚，但它可能代表心力衰竭时心脏交感神经张力的增强。
To evaluate myocardial catecholamine balance in heart failure, systemic hemodynamics, coronary sinus blood flow, and arterial and coronary sinus venous norepinephrine (NE) and epinephrine (E) concentrations were determined in 30 patients with chronic left ventricular failure (CHF), and in 25 patients with angina pectoris (AP) but without heart failure. In the group with CHF, stroke work index was lower (CHF 20 ± 9, AP 53 ± 13 g-m/m2, p <0.001) and pulmonary capillary wedge pressure higher (CHF 28 ± 8, AP 11 ± 4 mm Hg, p < 0.001), indicating depressed left ventricular function. Coronary sinus blood flow was similar in 2 groups (CHF 97 ± 70, AP 73 ± 32 ml/min, difference not significant). In the group with CHF, arterial (634 ± 582 pg/ml) and coronary sinus venous (1,038 ± 1,014 pg/ml) NE concentrations were significantly higher than in the group with AP (arterial 185 ± 135, coronary sinus 231 ± 167 pg/ml, p <0.001). The net myocardial NE release in patients with CHF was approximately 20 times higher than that in patients with AP (CHF 38,548 ± 48,622, AP 2,245 ± 10,242 pg/min, p <0.001). Arterial E and myocardial E uptake was similar in both groups. Although mechanisms for increased myocardial net NE release remains unknown, it probably represents enhanced cardiac sympathetic tone in response to heart failure.
影响因子：
158.5
作者：
BRISTOW, MR;GINSBURG, R;STINSON, EB
通讯作者：
STINSON, EB