Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.
Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.
复制标题
DOI：
10.1192/bjp.bp.114.154997
复制
发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Eley TC
中科院分区：
文献类型：
--
作者：
Lester KJ;Roberts S;Keers R;Coleman JR;Breen G;Wong CC;Xu X;Arendt K;Blatter-Meunier J;Bögels S;Cooper P;Creswell C;Heiervang ER;Herren C;Hogendoorn SM;Hudson JL;Krause K;Lyneham HJ;McKinnon A;Morris T;Nauta MH;Rapee RM;Rey Y;Schneider S;Schneider SC;Silverman WK;Smith P;Thastum M;Thirlwall K;Waite P;Wergeland GJ;Eley TC
背景我们先前报道了5HTTLPR基因型与儿童焦虑症认知行为治疗（CBT）后结果的相关性（队列1）。低表达短等位基因纯合子的儿童表现出更积极的结果。其他类似的研究产生了混合的结果，大多数报告基因型和CBT结果之间没有关联。目的是复制5HTTLPR和CBT结果之间的关联，在儿童焦虑的基因治疗研究（GxT队列2，n = 829）。方法采用Logistic和线性混合效应模型分析5HTTLPR与CBT疗效的关系。使用两个队列进行了大型分析。结果在队列2中，5HTTLPR对CBT结局无显著影响。大型分析确定了5HTTLPR与随访时所有焦虑症缓解之间的显著相关性（比值比0.45，P = 0.014），但与原发性焦虑症结局无关。结论5HTTLPR基因型与CBT预后无相关性。短等位基因纯合子表现出更积极的治疗结果，但影响较小，不显着。未来的研究将受益于利用全基因组方法和大型同质样本。
Background We previously reported an association between 5HTTLPR genotype and outcome following cognitive–behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome. Aims To replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829). Method Logistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed. Results There was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes. Conclusions The association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.