DNA polymorphic loci mapped to human chromosomes 3, 5, 9, 11, 17, 18, and 22.
DNA polymorphic loci mapped to human chromosomes 3, 5, 9, 11, 17, 18, and 22.
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DNA 多态性位点定位于人类 3、5、9、11、17、18 和 22 号染色体。
DOI：
10.1073/pnas.81.8.2447
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发表时间：
1984
影响因子：
11.1
通讯作者：
Shows,TB
中科院分区：
文献类型：
--
作者：
Naylor,SL;Sakaguchi,AY;Barker,D;White,R;Shows,TB
利用Southern杂交和体细胞遗传学技术，将7个识别DNA多态位点的基因组DNA片段定位到特定的染色体和染色体区域。从人类基因组文库中分离的七种探针缺乏重复序列，并与从一组分离人类染色体的人类-啮齿动物体细胞杂交体中分离的DNA杂交。这些探针检测人类染色体3、5、9、11、17、18和22上的DNA序列。这些DNA多态性位点，出现在10%或更多的人口，将作为标记与已知的多态性基因座的连锁研究，以及建立与疾病基因座的连锁。
Using the techniques of Southern filter hybridization and somatic cell genetics, seven genomic DNA fragments recognizing DNA polymorphic loci were mapped to specific chromosomes and regions of chromosomes. The seven probes, isolated from human genomic libraries, lacked repetitive sequences and were hybridized to DNA isolated from a set of human-rodent somatic cell hybrids segregating human chromosomes. These probes detected DNA sequences on human chromosomes 3, 5, 9, 11, 17, 18, and 22. These DNA polymorphic sites, which occur in 10% or greater of the population, will serve as markers for linkage studies with known polymorphic loci as well as to establish linkage with disease loci.