Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women.
Impact of depression and stress on placental DNA methylation in ethnically diverse pregnant women.
复制标题
抑郁和压力对不同种族孕妇胎盘DNA甲基化的影响
DOI：
10.2217/epi-2021-0192
复制
发表时间：
2021-09
期刊：
影响因子：
3.8
通讯作者：
M. Tesfaye;Suvo Chatterjee;Xuehuo Zeng;Paule Valery Joseph;F. Tekola-Ayele
中科院分区：
文献类型：
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作者：
M. Tesfaye;Suvo Chatterjee;Xuehuo Zeng;Paule Valery Joseph;F. Tekola-Ayele
Aim: To investigate the association between placental genome-wide methylation at birth and antenatal depression and stress during pregnancy. Methods: We examined the association between placental genome-wide DNA methylation (n = 301) and maternal depression and stress assessed at six gestation periods during pregnancy. Correlation between DNA methylation at the significantly associated CpGs and expression of nearby genes in the placenta was tested. Results: Depression and stress were associated with methylation of 16 CpGs and two CpGs, respectively, at a 5% false discovery rate. Methylation levels at two of the CpGs associated with depression were significantly associated with expression of ADAM23 and CTDP1, genes implicated in neurodevelopment and neuropsychiatric diseases. Conclusion: Placental epigenetic changes linked to antenatal depression suggest potential fetal brain programming. Clinical trial registration number: NCT00912132 (ClinicalTrials.gov).
