The Relationship of Malnutrition With Cognitive Function in the Older Chinese Population: Evidence From the Chinese Longitudinal Healthy Longevity Survey Study.
The Relationship of Malnutrition With Cognitive Function in the Older Chinese Population: Evidence From the Chinese Longitudinal Healthy Longevity Survey Study.
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中国老年人群营养不良与认知功能的关系：来自 CLHLS 研究的证据
DOI：
10.3389/fnagi.2021.766159
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发表时间：
2021
影响因子：
4.8
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Sun B;Zhao Y;Lu W;Chen Y
背景和目的：很少有研究探讨老年营养风险指数(GNRI)所衡量的营养不良与认知能力之间的关系。本研究旨在探讨中国人群营养不良与认知功能的关系。方法：前瞻性纵向研究，使用2011-2012年、2014年、2017-2018年三波中国纵向健康长寿调查(CLHLS)数据。年龄在60岁或以上且无精神疾病和脑血管疾病的参与者符合条件。营养状况指数用于评估营养状况如下：营养正常(GnRI；98)、轻度营养不良(92≤a GNRI≤98)、中到重度营养不良(GnRI<；92)。认知能力由简易智力状态检查(MMSE)评分评估。采用线性混合效应模型分析GNRI与认知功能的关系。结果：共分析了1632名受试者，其中男性741名，女性891名。其中，65.0%的受试者营养正常，19.4%的受试者营养不良，15.6%的受试者营养不良。在调整了潜在的混杂因素后，轻度和中重度营养不良患者的简明精神状态量表评分[β(95%CI)分别为-0.95(-1.60，-0.25)和-1.39(-2.21，-0.57)]低于营养正常者。在总体人群中，营养不良风险与认知功能之间存在线性关系[β(95%CI)：-0.74(-1.13，-0.35)]。然而，只有在90岁以上的文盲女性中，才观察到营养不良与认知功能的显著关联。结论：本研究提示中国老年人认知功能与GNRI之间存在显著的相关性。此外，营养不良越严重的受试者认知功能越差，尤其是年龄最大的文盲女性。临床医生应更加重视对老年人营养和认知状况的评估，及时干预和预防认知障碍。
Background and Objective: Few studies have explored the relationship between malnutrition measured by the Geriatric Nutritional Risk Index (GNRI) and cognitive performance. This study aimed to investigate the association of malnutrition with cognitive function in the Chinese population. Methods: It was a prospective longitudinal study and used three waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) data in 2011–2012, 2014, and 2017–2018. Participants aged 60 years or older without mental illness and cerebrovascular diseases were eligible. The GNRI was used to assess nutritional status as follows: normal nutrition (a GNRI > 98), mild malnutrition (92 ≤ a GNRI ≤ 98), and moderate-to-severe malnutrition (a GNRI < 92). Cognitive performance was evaluated by the Mini-Mental State Examination (MMSE) scores. The relationship between the GNRI and cognitive function was analyzed using a linear mixed-effects model. Results: A total of 1,632 subjects were analyzed, including 741 males and 891 females. Of these, 65.0, 19.4, and 15.6% of subjects were at normal nutritional status, mild, and moderate-to-severe malnutrition, respectively. After adjusting for potential confounders, participants under mild and moderate-to-severe malnutrition status have a lower MMSE score [β (95% CI): –0.95 (–1.60, –0.25) and –1.39 (–2.21, –0.57), respectively], compared with those having normal nutrition. Also, there was a linear trend in the association of malnutrition risk with cognitive function in the total population [β (95% CI): –0.74 (–1.13, –0.35)]. However, a significant association of malnutrition with cognitive function was observed only among illiterate females aged above 90 years. Conclusion: This study suggested that there was a significant relationship between the GNRI and cognitive function in the Chinese elderly. Furthermore, subjects with more serious malnutrition have a worse cognitive function, especially in the oldest illiterate females. Clinicians should put more emphasis on assessing the nutritional and cognitive status of the elderly to timely intervene and prevent cognitive impairment.
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影响因子：
7.1
作者：
Bouillanne, O;Morineau, G;Aussel, C
通讯作者：
Aussel, C
DOI：
10.1016/j.jamda.2020.10.020
发表时间：
2023-04-27
影响因子：
7.6
作者：
Doorduijn, Astrid S.;de van der Schueren, Marian A. E.;Visser, Marjolein
通讯作者：
Visser, Marjolein
DOI：
10.20960/nh.657
发表时间：
2017-08-01
期刊：
Nutrición Hospitalaria
影响因子：
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作者：
Leiva Badosam, Elisabet;Badia Tahull, María;Llop Talaveron, Josep Manel
通讯作者：
Llop Talaveron, Josep Manel
影响因子：
17.7
作者：
Hill, Nicole T. M.;Mowszowski, Loren;Lampit, Amit
通讯作者：
Lampit, Amit
影响因子：
4.2
作者：
Lackoff, Ariel S.;Hickling, Donna;Bell, Jack J.
通讯作者：
Bell, Jack J.