Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models
Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models
复制标题
DOI：
10.1118/1.1428758
复制
发表时间：
2002-02-01
期刊：
影响因子：
3.8
通讯作者：
Zamenhof, RG
中科院分区：
文献类型：
--
作者：
Goorley, JT;Kiger, WS;Zamenhof, RG
随着中子俘获疗法（NCT）在美国和其他国家的临床试验启动，新的治疗计划代码正在开发中，以便在特定患者模型中计算详细的剂量分布。对治疗计划代码进行全面评估和比较是实现剂量测定最终标准化的关键一步，而剂量测定的标准化反过来又是合理比较不同机构临床结果的一个基本要素。在本文中，我们报告了一套用于NCT剂量测定的计算测试问题参考方案的开发情况，并讨论了在这些计算中遇到的常见问题，以促进对NCT治疗计划代码进行定量评估和比较。具体而言，使用蒙特卡罗辐射输运代码MCNP4B，针对改进的斯奈德头部体模的四种不同表示形式计算了详细的深度比释动能率曲线，这四种形式分别是：一个解析的、多层的椭圆体模型，以及该模型的体素表示形式，其立方体体素大小分别为16、8和4毫米。分别模拟了能量为0.0253电子伏特、1、2、10、100和1000千电子伏特的单能单向中子束，以及0.2、0.5、1、2、5和10兆电子伏特的光子束，以计算比释动能率，统计不确定度为……
As clinical trials of Neutron Capture Therapy (NCT) are initiated in the U.S. and other countries, new treatment planning codes are being developed to calculate detailed dose distributions in patient-specific models. The thorough evaluation and comparison of treatment planning codes is a critical step toward the eventual standardization of dosimetry, which, in turn, is an essential element for the rational comparison of clinical results from different institutions. In this paper we report development of a reference suite of computational test problems for NCT dosimetry and discuss common issues encountered in these calculations to facilitate quantitative evaluations and comparisons of NCT treatment planning codes. Specifically, detailed depth-kerma rate curves were calculated using the Monte Carlo radiation transport code MCNP4B for four different representations of the modified Snyder head phantom, an analytic, multishell, ellipsoidal model, and voxel representations of this model with cubic voxel sizes of 16, 8, and 4 mm. Monoenergetic and monodirectional beams of 0.0253 eV, 1, 2, 10, 100, and 1000 keV neutrons, and 0.2, 0.5, 1, 2, 5, and 10 MeV photons were individually simulated to calculate kerma rates to a statistical uncertainty of