Contextual cueing impairment in patients with age-related macular degeneration
Contextual cueing impairment in patients with age-related macular degeneration
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DOI：
10.1167/13.3.28
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发表时间：
2013-01-01
影响因子：
1.8
通讯作者：
Pollmann, Stefan
中科院分区：
文献类型：
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作者：
Geringswald, Franziska;Herbik, Anne;Pollmann, Stefan
视觉注意力可以通过我们视觉环境中过去的规律性经验来引导。在上下文提示范例中，与随机搜索阵列相比，重复干扰项配置的偶然学习可以加快搜索时间。与此同时，更少的注视和更直接的扫描路径表明重复搜索阵列中的视觉探索更有效。在之前的工作中，我们发现在健康观察者中模拟中心暗点消除了这种搜索便利性。在这里，我们研究了患有黄斑中心凹视力受损的年龄相关性黄斑变性（AMD）患者的情境提示。 AMD 患者仅使用受损较严重的眼睛 (n = 13) 以及双眼观察 (n = 16) 进行视觉搜索。正常视力的对照产生了显着的上下文提示效应。相比之下，当患者用较差的眼睛进行搜索时，重复显示仅显示出很小的、不显着的优势。当双眼搜索时，他们从上下文线索中获益，但仍然少于对照组。注视次数和扫描模式比率显示出与搜索时间相当的模式。此外，上下文提示与单眼搜索的敏锐度显着相关。因此，中央凹视力丧失可能会导致情境记忆线索对注意力的引导受损。
Visual attention can be guided by past experience of regularities in our visual environment. In the contextual cueing paradigm, incidental learning of repeated distractor configurations speeds up search times compared to random search arrays. Concomitantly, fewer fixations and more direct scan paths indicate more efficient visual exploration in repeated search arrays. In previous work, we found that simulating a central scotoma in healthy observers eliminated this search facilitation. Here, we investigated contextual cueing in patients with age-related macular degeneration (AMD) who suffer from impaired foveal vision. AMD patients performed visual search using only their more severely impaired eye (n = 13) as well as under binocular viewing (n = 16). Normal-sighted controls developed a significant contextual cueing effect. In comparison, patients showed only a small nonsignificant advantage for repeated displays when searching with their worse eye. When searching binocularly, they profited from contextual cues, but still less than controls. Number of fixations and scan pattern ratios showed a comparable pattern as search times. Moreover, contextual cueing was significantly correlated with acuity in monocular search. Thus, foveal vision loss may lead to impaired guidance of attention by contextual memory cues.