Executive functioning in anorexia nervosa patients and their unaffected relatives
Executive functioning in anorexia nervosa patients and their unaffected relatives
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DOI：
10.1016/j.psychres.2012.10.001
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发表时间：
2013-08-15
影响因子：
11.3
通讯作者：
Bellodi, Laura
中科院分区：
文献类型：
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作者：
Galimberti, Elisa;Fadda, Emma;Bellodi, Laura
正式的遗传学研究表明，神经性厌食症（AN）的遗传影响很大，但目前的结果不一致。使用神经认知内表型方法可能有助于我们理解AN的病理生理学。我们调查了AN患者（n=29）及其未受影响的亲属（n = 29）与健康先证者（n = 29）及其亲属（n= 29）的决策，设置转移和计划。采用爱荷华州赌博任务（IGT）、河内塔（ToH）和威斯康星州卡片分类测验（WCST）。还计算了先证者/亲属的一致率和遗传力指数。在AN先证者及其亲属中发现IGT和WCST的表现受损，尽管计划似乎被保留。IGT遗传力指数表明存在影响该指标的遗传效应。没有证据表明遗传效应被发现的WCST。结果表明，存在一个共享的功能失调的执行配置文件中的妇女与AN和他们的未受影响的亲属，其特点是决策不足和集转移。一致性分析强烈表明，这些障碍聚集在AN家庭，支持的假设，他们可能构成AN的生物学标记。决策障碍呈现中等遗传力，这表明决策可能是AN的候选内表型。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Formal genetic studies suggested a substantial genetic influence for anorexia nervosa (AN), but currently results are inconsistent. The use of the neurocognitive endophenotype approach may facilitate our understanding of the AN pathophysiology. We investigated decision-making, set-shifting and planning in AN patients (n=29) and their unaffected relatives (n=29) compared to healthy probands (n=29) and their relatives (n=29). The Iowa Gambling Task (IGT), the Tower of Hanoi (ToH) and the Wisconsin Card Sorting Test (WCST) were administered. Concordance rates and heritability indices were also calculated in probands/relatives. Impaired performance on the IGT and the WCST were found in both AN probands and their relatives, although planning appeared to be preserved. The IGT heritability index suggested the presence of genetic effects that influence this measure. No evidence for genetic effects was found for the WCST. The results suggest the presence of a shared dysfunctional executive profile in women with AN and their unaffected relatives, characterized by deficient decision-making and set-shifting. Concordance analysis strongly suggests that these impairments aggregate in AN families, supporting the hypothesis that they may constitute biological markers for AN. Decision-making impairment presents a moderate heritability, suggesting that decision-making may be a candidate endophenotype for AN. (C) 2012 Elsevier Ireland Ltd. All rights reserved.