Exploration of the potential of liquid scintillators for real-time 3D dosimetry of intensity modulated proton beams
Exploration of the potential of liquid scintillators for real-time 3D dosimetry of intensity modulated proton beams
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DOI：
10.1118/1.3117583
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发表时间：
2009-05-01
期刊：
影响因子：
3.8
通讯作者：
Mohan, Radhe
中科院分区：
文献类型：
--
作者：
Beddar, Sam;Archambault, Louis;Mohan, Radhe
在这项研究中，作者研究了使用三维液体闪烁体（LS）探测器系统实时验证和表征质子束的可行性，用于强度和能量调制质子治疗。用原始质子布拉格峰照射装有液体闪烁体的塑料罐。用CCD相机测量辐照过程中产生的闪烁光。采用20帧/秒和10帧/秒的采集速率对连续帧序列进行成像。然后将这些测量结果与离子室测量结果和蒙特卡罗模拟结果进行比较。在Bragg曲线的高原区域，以20和10 fps的速率获得的图像测量的光分布的标准偏差分别为1.1%和0.7%。由于LS的猝灭效应和成像系统的光学特性，在原始LS信号和离子室之间可以看到差异。作者表明，这种影响可以通过蒙特卡罗模拟来解释和纠正。液体闪烁体探测器系统在快速质子束验证和表征方面具有良好的潜力。
In this study, the authors investigated the feasibility of using a 3D liquid scintillator (LS) detector system for the verification and characterization of proton beams in real time for intensity and energy-modulated proton therapy. A plastic tank filled with liquid scintillator was irradiated with pristine proton Bragg peaks. Scintillation light produced during the irradiation was measured with a CCD camera. Acquisition rates of 20 and 10 frames per second (fps) were used to image consecutive frame sequences. These measurements were then compared to ion chamber measurements and Monte Carlo simulations. The light distribution measured from the images acquired at rates of 20 and 10 fps have standard deviations of 1.1% and 0.7%, respectively, in the plateau region of the Bragg curve. Differences were seen between the raw LS signal and the ion chamber due to the quenching effects of the LS and due to the optical properties of the imaging system. The authors showed that this effect can be accounted for and corrected by Monte Carlo simulations. The liquid scintillator detector system has a good potential for performing fast proton beam verification and characterization.