One piece ultracompact totally implantable electromechanical total artificial heart for permanent use.
One piece ultracompact totally implantable electromechanical total artificial heart for permanent use.
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一件式超紧凑型完全植入式机电全人工心脏，可永久使用。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
H. Arai
中科院分区：
文献类型：
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作者：
S. Takatani;T. Sakamoto;K. Ohuchi;M. Nakamura;T. Mizuno;H. Arai
一种超紧凑、一体式、完全植入式机电全人工心脏（TAH）已被开发为衰竭心脏的永久替代品。它由钛合金（Ti-6Al-7 Nb）制成的左、右推板血泵（冲程容积55 ml）组成，在它们之间装有一个小型机电致动器。TAH的直径为90 mm，厚度为70 mm，总体积为400 ml。重量为450 g。虽然它是小型化的，但它提供了8 L/min的最大泵输出，而左后负荷为100 mm Hg。它需要大约12瓦来提供6.5 L/min的泵输出，最大效率为13.5%。为了平衡左右流量，右冲程长度比左冲程短10%，并且使用辅助顺应性腔室来补偿它们之间的额外流量差异。电机换向脉冲和霍尔效应推板传感器信号用于控制器中，以实现左主交替可变速率模式。小腿拟合研究显示了良好的解剖兼容性，并于2001年12月获得了第一个成功的幸存者。需要对系统耐久性和生物相容性进行研究，以确保长期可靠性。该TAH有望用于衰竭心脏的永久性置换以及用于较小规模的终末期心脏病患者的心脏移植的桥接。
An ultracompact, one piece, totally implantable electromechanical total artificial heart (TAH) has been developed as a permanent replacement for failing hearts. It consists of left and right pusher plate blood pumps (stroke volume 55 ml) made of titanium alloy (Ti-6Al-7Nb) sandwiching a miniaturized electromechanical actuator between them. The diameter of the TAH is 90 mm, with a thickness of 70 mm, yielding an overall volume of 400 ml. It weighs 450 g. Although it is miniaturized, it provided a maximum pump output of 8 L/min against a left afterload of 100 mm Hg. It required approximately 12 watts to provide a pump output of 6.5 L/min with maximum efficiency of 13.5%. To balance left and right flow, the right stroke length was made 10% shorter than the left, and an auxiliary compliance chamber was used to compensate for additional flow differences between them. Motor commutation pulses and a Hall effect pusher plate sensor signal were used in the controller to implement the left master alternate variable rate mode. The calf fitting study revealed excellent anatomic compatibility, and the first successful survivor was obtained in December 2001. Studies of system endurance and biocompatibility are required to ensure long-term reliability. This TAH is promising for permanent replacement of the failing heart as well as for bridge to heart transplantation for the smaller size group of end-stage cardiac patients.
用于 LVAS 的新型纹理表面胸腔内可变容量装置取得了可喜的结果。
DOI：
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发表时间：
1981
期刊：
Transactions - American Society for Artificial Internal Organs
影响因子：
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作者：
Snow,J;Harasaki,H;Kasick,J;Whalen,R;Kiraly,R;Nose,Y
通讯作者：
Nose,Y