The relationship between the anti-Porphyromonas gingivalis immunoglobulin G subclasses antibodies and small for gestational age delivery: A longitudinal study in Japanese pregnant women
The relationship between the anti-Porphyromonas gingivalis immunoglobulin G subclasses antibodies and small for gestational age delivery: A longitudinal study in Japanese pregnant women
复制标题
抗牙龈卟啉单胞菌免疫球蛋白G亚类抗体与小于胎龄儿分娩的关系：日本孕妇的纵向研究
DOI：
10.1111/idj.12548
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发表时间：
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影响因子：
3.3
通讯作者：
Yuichi Izumi
中科院分区：
文献类型：
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作者：
Changchang Ye;Hiroaki Kobayashi;Sayaka Katagiri;Naoyuki Miyasaka;Yasuo Takeuchi;Ryutaro Kuraji;Yuichi Izumi
背景针对牙龈卟啉单胞菌的母体血清 IgG 抗体是牙周炎和不良妊娠结局的指标。本研究旨在评估抗 P。先兆早产 (TPL) 患者中的 gingivalisIgG 和 IgG 亚类 1-4 及其与小于胎龄 (SGA) 的关联。方法从 47 名 TPL 患者和 48 名健康孕妇中收集血清、唾液和龈下菌斑样本。 P 的量。使用实时聚合酶链反应测量唾液和牙菌斑中的牙龈炎。血清抗P。 gingivalisIgG 滴度和抗 P。使用酶联免疫吸附测定法测量牙龈炎亚类 IgG 1-4 浓度。 TPL 组的 gingivalisIgG-1 显着低于健康组。 TPL 组中有 14 名受试者分娩了 SGA 婴儿。口袋探诊深度 (PPD)、临床附着丧失、PPD ≥ 5 mm%、P 量。牙龈素菌斑，抗 P. gingivalisIgG 和抗 P。 TPL-SGA 组中的 gingivalisIgG-4 显着高于 TPL-正常体重组。此外，逻辑回归分析揭示了P的检测频率。 TPL 中牙龈素菌斑和胎盘重量与 SGA 显着相关。 在接受者操作特征曲线分析中，量为P。牙龈素菌斑≥86.45 拷贝显示预测 TPL 中 SGA 的敏感性为 0.786，特异性为 0.727 (AUC 0.792)。 gingivalisIgG-1 含量与 TPL 相关，而抗 P 含量较高。 gingivalisIgG和IgG-4与TPL中的SGA相关。此外，P的更大定植。牙龈素菌斑可能会增加 SGA 的风险，并且可用于预测 TPL 中的 SGA。
BackgroundMaternal serum IgG antibody againstPorphyromonas gingivalisis an indicator of both periodontitis and adverse pregnancy outcomes. This study aims to evaluate the anti‐P. gingivalisIgG and IgG subclasses1–4 in threatened preterm labour (TPL) patients and their association with small for gestational age (SGA).MethodsSerum, saliva and subgingival plaque samples were collected from 47 TPL patients compared with 48 healthy pregnant women. The amount ofP. gingivaliswas measured in saliva and plaque using real‐time polymerase chain reaction. The serum anti‐P. gingivalisIgG titre and anti‐P. gingivalissubclasses IgG 1–4 concentration were measured using enzyme‐linked immunosorbent assay.ResultsThe amount of anti‐P. gingivalisIgG‐1 was significantly lower in the TPL group than in the healthy group. Fourteen subjects delivered SGA infants in the TPL group. The pocket probing depth (PPD), clinical attachment loss, PPD ≥ 5 mm%, amount ofP. gingivalisin plaque, anti‐P. gingivalisIgG and anti‐P. gingivalisIgG‐4 were significantly higher in the TPL‐SGA group than in the TPL‐normal weight group. Moreover, logistic regression analysis revealed the detection frequency ofP. gingivalisin plaque and placenta weight were significantly correlated with SGA in TPL. In the receiver operating characteristic curve analysis, an amount ofP. gingivalisin plaque ≥ 86.45 copies showed a sensitivity of 0.786 and a specificity of 0.727 (AUC 0.792) for predicting SGA in TPL.ConclusionLower anti‐P. gingivalisIgG‐1 amounts are related to TPL, while higher anti‐P. gingivalisIgG and IgG‐4 are related with SGA in TPL. Further, greater colonisation ofP. gingivalisin plaque might increase the risk of SGA and can be useful in prediction of SGA in TPL.