Cluster randomized trials of cancer screening interventions: Are appropriate statistical methods being used?
Cluster randomized trials of cancer screening interventions: Are appropriate statistical methods being used?
复制标题
DOI：
10.1016/j.cct.2011.03.001
复制
发表时间：
2011-07-01
影响因子：
2.2
通讯作者：
Wu, Sheng
中科院分区：
文献类型：
--
作者：
Crespi, Catherine M.;Maxwell, Annette E.;Wu, Sheng
整群随机试验的设计和分析可能需要比个体随机试验更复杂的技术。然而，并不总是认识到需要有统计方法来说明分组设计，过去的审查发现方法和报告方面普遍存在缺陷。我们回顾了1995-2010年发表的癌症筛查干预措施的随机分组试验，以确定适当统计方法的使用是否随着时间的推移而增加。文献检索得到50篇文章，报告了乳腺癌、宫颈癌和结直肠癌筛查干预措施的群集随机试验的结局分析。在1995-1999年、2000-2002年、2003-2006年和2007- 2010年发表的研究中，分别有55%（6/11）、82%（9/11）、92%（12/13）和60%（9/15）采用了适当的分析方法。结果表明，2003-2006年达到峰值（p = .06），随后在2007-2010年下降（p = .08）。虽然研究样本较小，但这些结果表明，许多癌症筛查干预措施的随机分组试验在应用正确的统计程序进行结果分析方面存在缺陷，并且在2000年代早期和中期增加采用适当的方法可能无法持续。(C)2011 Elsevier Inc. All rights reserved.
The design and analysis of cluster randomized trials can require more sophistication than individually randomized trials. However, the need for statistical methods that account for the clustered design has not always been appreciated, and past reviews have found widespread deficiencies in methodology and reporting. We reviewed cluster randomized trials of cancer screening interventions published in 1995-2010 to determine whether the use of appropriate statistical methods had increased over time. Literature searches yielded 50 articles reporting outcome analyses of cluster randomized trials of breast, cervix and colorectal cancer screening interventions. Of studies published in 1995-1999, 2000-2002, 2003-2006 and 2007-2010,55% (6/11), 82% (9/11), 92% (12/13) and 60% (9/15) used appropriate analytic methods, respectively. Results were suggestive of a peak in 2003-2006 (p = .06) followed by a decline in 2007-2010 ( p = .08). While the sample of studies was small, these results indicate that many cluster randomized trials of cancer screening interventions have had deficiencies in the application of correct statistical procedures for the outcome analysis, and that increased adoption of appropriate methods in the early and mid-2000's may not have been sustained. (C) 2011 Elsevier Inc. All rights reserved.