Lifespan extension in Caenorhabditis elegans by complete removal of food
Lifespan extension in Caenorhabditis elegans by complete removal of food
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DOI：
10.1111/j.1474-9726.2006.00238.x
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发表时间：
2006-12-01
期刊：
影响因子：
7.8
通讯作者：
Kaeberlein, Matt
中科院分区：
文献类型：
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作者：
Kaeberlein, Tammi L.;Smith, Erica D.;Kaeberlein, Matt
在许多不同的生物体中，部分减少食物摄入量可以延长寿命。我们在这里报告一个新的饮食限制方案的线虫秀丽隐杆线虫，标准的琼脂平板寿命测定的基础上，在没有细菌食物来源的情况下，其中成年蠕虫保持。这些发现代表了第一份关于任何有机体因长期饥饿而延长寿命的报告。去除细菌食物比部分减少食物更大程度地增加寿命，其机制与胰岛素/IGF样信号传导和Sir 2家族脱乙酰酶SIR-2.1不同。在繁殖后的成年人中开始时，去除细菌食物也会增加寿命，这表明在中年期间开始的饮食限制可以导致独立于繁殖的显著长寿益处。
A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. These findings represent the first report in any organism of lifespan extension in response to prolonged starvation. Removal of bacterial food increases lifespan to a greater extent than partial reduction of food through a mechanism that is distinct from insulin/IGF-like signaling and the Sir2-family deacetylase, SIR-2.1. Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction.