Learning-induced changes in the neural circuits underlying motor sequence execution.
Learning-induced changes in the neural circuits underlying motor sequence execution.
复制标题
学习引起的运动序列执行的神经回路发生变化。
DOI：
10.1016/j.conb.2022.102624
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发表时间：
2022
影响因子：
5.7
通讯作者：
Ölveczky,BenceP
中科院分区：
文献类型：
--
作者：
KadmonHarpaz,Naama;Hardcastle,Kiah;Ölveczky,BenceP
正如一句古老的谚语所说：熟能生巧。然而，人们对机械重复将停顿行为转变为流畅、轻松和“自动”行动的神经机制还没有很好的理解。在这里，我们考虑的可能性，练习良好的运动序列，最初依赖于较高级别的决策电路，成为完全指定在较低级别的控制电路。我们回顾研究告知这一想法，讨论这种转变的控制的限制，并提出方法来查明与运动序列学习相关的电路水平的变化。
As the old adage goes: practice makes perfect. Yet, the neural mechanisms by which rote repetition transforms a halting behavior into a fluid, effortless, and “automatic” action are not well understood. Here we consider the possibility that well-practiced motor sequences, which initially rely on higher-level decision-making circuits, become wholly specified in lower-level control circuits. We review studies informing this idea, discuss the constraints on such shift in control, and suggest approaches to pinpoint circuit-level changes associated with motor sequence learning.