MECHANISMS OF EARLY NEUROGENESIS IN DROSOPHILA-MELANOGASTER
MECHANISMS OF EARLY NEUROGENESIS IN DROSOPHILA-MELANOGASTER
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DOI：
10.1002/neu.480241005
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发表时间：
1993-10-01
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影响因子：
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通讯作者：
CAMPOSORTEGA, JA
中科院分区：
文献类型：
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作者：
CAMPOSORTEGA, JA
昆虫的神经外胚层包含最初无关的细胞群体，其在以后的发育期间将产生神经和表皮谱系的祖细胞。实验证据表明，细胞间的相互作用决定了哪些细胞将接受这些命运中的每一种。移植实验表明，需要具有神经化特征的信号来稳定25%的所有神经外胚层细胞中的初级神经命运，其将发育为成神经细胞，并且表皮化信号有助于抑制剩余75%的细胞中的神经命运，以这种方式允许它们发育为表皮祖细胞。被调用的细胞相互作用被认为是由几个基因的产物介导的，这些基因形成了一个复杂的、尚未被很好理解的相互关系网络。这个网络的元素是由Delta和Notch编码的蛋白质，它们似乎在细胞之间传递调节信号;由无毛鳞片基因复合物编码的蛋白质，它们调节神经发育;以及由分裂基因复合物增强子编码的蛋白质，它们使神经外胚层细胞进入表皮发育。(C)John Wiley & Sons，Inc.
The neuroectoderm of insects contains an initially indifferent population of cells which during later development will give rise to the progenitor cells of the neural and epidermal lineages. Experimental evidence indicates that cellular interactions determine which cells will adopt each one of these fates. Transplantation experiments suggest that a signal with neuralising character is required to stabilize the primary neural fate in 25% of all the neuroectodermal cells, which will develop as neuroblasts, and that an epidermalising signal contributes to suppress the neural fate in the remaining 75% of the cells, allowing in this way their development as epidermal progenitor cells. The invoked cell interactions are assumed to be mediated by the products of several genes forming a complex, not yet well understood network of interrelationships. Elements of this network are the proteins encoded by Delta and Notch, which appear to convey the regulatory signals between the cells; the proteins encoded by the achaete-scute gene complex, which regulate neural development; and the proteins encoded by the Enhancer of split gene complex, which give neuroectodermal cells access to epidermal development. (C) 1993 John Wiley & Sons, Inc.