DETERMINANTS OF HOST RANGE O FELINE LEUKEMIA VIRUSES
DETERMINANTS OF HOST RANGE O FELINE LEUKEMIA VIRUSES
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DOI：
10.1099/0022-1317-20-2-169
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发表时间：
1973-01-01
影响因子：
3.8
通讯作者：
HAY, D
中科院分区：
文献类型：
--
作者：
JARRETT, O;LAIRD, HM;HAY, D
B 亚型和 C 亚型的猫白血病病毒在人类和犬类细胞中繁殖，而 A 亚型病毒则不能。这种宿主范围限制是由病毒包膜决定的，并在病毒进入细胞的水平上起作用。当 A 亚组病毒基因组被引入 B 亚组包膜内并进入人类或狗细胞时，它们就会被表达和复制。因此，由于它们是 A 和 B 亚组病毒的表型混合物，大多数猫白血病病毒分离株将感染人类和犬类细胞，随后产生每个亚组的 FeLV。
Feline leukaemia viruses of subgroups B and C multiply in human and canine cells, while subgroup A viruses do not. This host range restriction is determined by the virus envelope and operates at the level of virus entry into the cell. Subgroup A virus genomes are expressed and replicated when they are introduced within B subgroup envelopes into human or dog cells. Therefore, since they are phenotypic mixtures of A and B subgroup viruses, the majority of feline leukaemia virus isolates will infect human and canine cells with the subsequent production of FeLV of each subgroup.