Ultrasonic measurement of glomerular diameters in normal adult humans
Ultrasonic measurement of glomerular diameters in normal adult humans
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DOI：
10.1016/s0301-5629(96)00142-1
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发表时间：
1996-01-01
影响因子：
2.9
通讯作者：
Cox, GG
中科院分区：
文献类型：
--
作者：
Hall, TJ;Insana, MF;Cox, GG
在2-4 MHz频率范围内，对50名正常成人志愿者的肾皮质进行了超声测量，以确定超声测量结果在临床条件下的灵敏度。发现该组的平均肾小球直径为216 ± 27 μ m（SD）。发现肾小球大小与体表面积相关（r = 0.4），并且发现肾小球表面积与体表面积之比（GSA/BSA）在正常成年生活中是恒定的，GSA/BSA =（8.24 +/- 1.35）x 10（-8）（SD）。这些结果与文献中发现的组织学分析一致。在一个个体中，GSA/BSA的标准误为7%是典型的，在BSA不匹配的组中，生物学变异性主导散射体大小估计的方差，其中它占方差的47%，在BSA匹配的个体组中，生物学变异性仅占方差的21%，日常变异性占方差的35%;如果大于2 × SD的偏差被认为是异常的，则该技术可以潜在地检测个体内小至30 μ m的肾小球直径的变化。为了检测个体的异常GSA/BSA值，GSA/BSA必须与该组的平均值相差约3.6 x 10（-8）或约40%。因此，此时散射体尺寸估计对于随时间跟踪个体的疾病进展和治疗似乎是最可靠的。版权所有（C）1996世界医学和生物学超声联合会
The average size of acoustic scatterers and the integrated backscatter coefficient of kidney cortex were measured in vivo from 2-4 MHz for a group of 50 normal adult volunteers, Our goal was to determine the sensitivity of the ultrasonic measurements under clinical conditions by identifying biologic sources of estimation uncertainty, Based on 10 measurements on each kidney of each volunteer, the average glomerular diameter for the group was found to be 216 +/- 27 mu m (SD). Glomerular size was found to correlate with body surface area (r = 0.4), and the ratio of glomerular surface area to body surface area (GSA/BSA) was found to be constant throughout normal adult life with GSA/BSA = (8.24 +/- 1.35) x 10(-8) (SD). These results are consistent with histologic analyses found in the literature. Within an individual, 7% standard errors in GSA/BSA are typical, Biologic variability dominates the variance in scatterer size estimates in a group not matched for BSA, where it accounts for 47% of the variance, In a group of individuals matched for BSA, biologic variability accounts for only 21% of the variance; day-to-day variability accounts for 35% of the variance; and experimental parameters account for the remainder, If a deviation greater than 2 x SD is considered abnormal, then this technique can potentially detect changes in glomerular diameter as small as 30 mu m within an individual, To detect abnormal GSA/BSA values for an individual, GSA/BSA would have to differ from the mean for that group by about 3.6 x 10(-8) or about 40%. Therefore, at this time scatterer size estimates appear most reliable for tracking the progression of disease and treatment for an individual over time. Copyright (C) 1996 World Federation for Ultrasound in Medicine & Biology