Secondary electrospray ionization ion mobility spectrometry/mass spectrometry of illicit drugs
Secondary electrospray ionization ion mobility spectrometry/mass spectrometry of illicit drugs
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DOI：
10.1021/ac9907235
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发表时间：
2000-01-15
影响因子：
7.4
通讯作者：
Hill, HH
中科院分区：
文献类型：
--
作者：
Wu, C;Siems, WF;Hill, HH
提出了一种二次电喷雾电离（SESI）方法，作为离子迁移谱（IMS）的非放射性电离源。这种SESI方法依赖于电喷雾电离（ESI）产生的带电粒子和中性气体样品分子之间的气相相互作用。在离子迁移率分离后，使用质谱（MS）作为检测方法进行离子鉴定。初步的研究集中在了解SESI的电离过程。通过确定分析优值，评价了ESI-IMS和SESI-IMS用于非法药物检测的性能。在一般情况下，SESI有一个更高的电离效率为小的挥发性分子相比，电喷雾方法。开发一个通用接口的GC-和LC-MS与流动性分离的附加阶段的潜力被证明。
A secondary electrospray ionization (SESI) method was developed as a nonradioactive ionization source for ion mobility spectrometry (IMS). This SESI method relied on the gas-phase interaction between charged particles created by electrospray ionization (ESI) and neutral gaseous sample molecules. Mass spectrometry (MS) was used as the detection method after ion mobility separation for ion identification. Preliminary investigations focussed on understanding the ionization process of SESI. The performance of ESI-IMS and SESI-IMS for illicit drug detection was evaluated by determining the analytical figures of merit. In general, SESI had a higher ionization efficiency for small volatile molecules compared with the electrospray method. The potential of developing a universal interface for both GC- and LC-MS with an addition stage of mobility separation was demonstrated.