Lymphocytes in cancer development: polarization towards pro-tumor immunity.
Lymphocytes in cancer development: polarization towards pro-tumor immunity.
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DOI：
10.1016/j.cytogfr.2009.11.002
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发表时间：
2010-02
影响因子：
13
通讯作者：
Coussens, Lisa M.
中科院分区：
文献类型：
--
作者：
Ruffell, Brian;DeNardo, David G.;Affara, Nesrine I.;Coussens, Lisa M.
免疫细胞在癌症中的作用主要是肿瘤排斥的经典观点已经被具有促肿瘤和抗肿瘤特性的白细胞的更复杂观点所取代。这种转变是由于现在公认的几种骨髓细胞类型促进癌前组织的促肿瘤编程的能力，以及发现白细胞亚群也抑制对介导抗肿瘤免疫重要的淋巴细胞的发育和效应子功能。在这篇综述中，我们重点关注T淋巴细胞在促进肿瘤发展中未被充分认识的作用。除了调节性T细胞的作用外，这还包括自然杀伤T细胞和CD4+ T辅助细胞在抑制抗肿瘤免疫和促进癌症生长和转移中的作用。
The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro-and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4+ T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.
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影响因子：
15.3
作者：
Croft, Michael;Carter, Laura;Swain, Susan L.;Dutton, Richard W.
通讯作者：
Dutton, Richard W.
DOI：
10.1111/j.1600-0897.2005.00330.x
发表时间：
2005-12-01
影响因子：
3.6
作者：
Barnett, B;Kryczek, I;Curiel, TJ
通讯作者：
Curiel, TJ
影响因子：
32.4
作者：
Cao, Xuefang;Cai, Sheng F.;Ley, Timothy J.
通讯作者：
Ley, Timothy J.
DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Chen, Zhi;Laurence, Arian;O'Shea, John J.
通讯作者：
O'Shea, John J.
用抗L3T4抗体治疗后鼠淋巴瘤的免疫学介导的回归。从产生主要是Lyt-2+ T细胞介导的免疫力的宿主中去除L3T4+抑制T细胞的结果。
DOI：
10.1084/jem.168.6.2193
发表时间：
1988-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Awwad M;North RJ
通讯作者：
North RJ