Simplified reference tissue model for PET receptor studies
Simplified reference tissue model for PET receptor studies
复制标题
DOI：
10.1006/nimg.1996.0066
复制
发表时间：
1996-12-01
期刊：
影响因子：
5.7
通讯作者：
Hume, SP
中科院分区：
文献类型：
--
作者：
Lammertsma, AA;Hume, SP
参考组织模型允许在不测量动脉输入功能的情况下量化受体动力学，从而避免了动脉插管和耗时的代谢物测量。该模型包含四个参数，其中结合势(BP)是感兴趣的参数。尽管BP是稳健的，但收敛速度很慢，其他参数可能会有很大的标准误差。为了克服这一问题，开发了一种只包含三个参数的简化参考组织。这个新的三参数模型与以前的四参数模型进行了比较，使用了各种正电子发射计算机断层扫描研究：人体的[C-11]SCH 23390(D-1受体)和[C-11]拉氯普利(D-2受体)，以及大鼠的[C-11]SCH 23390，[C-11]拉氯普利和[C-11]RTI-121(多巴胺转运体)。对于所有病例，从两个模型获得的BP值基本相同。此外，三参数模型对初始值不敏感，对其他参数的结果稳定(标准差较小)，收敛速度快，因此，对于被测试的配体，三参数模型是一种更好的选择，结合了更快的收敛速度和更高的稳定性。(C)1996年学术出版社。
The reference tissue model allows for quantification of receptor kinetics without measuring the arterial input function, thus avoiding arterial cannulation and time-consuming metabolite measurements. The model contains four parameters, of which the binding potential (BP) is the parameter of interest. Although BP is robust, convergence rates are slow and the other parameters can have large standard errors. To overcome this problem, a simplified reference tissue containing only three parameters was developed. This new three-parameter model was compared with the previous four-parameter model using a variety of PET studies: [C-11]SCH 23390 (D-1 receptor) and [C-11]raclopride (D-2 receptor) in humans, and [C-11]SCH 23390, [C-11]raclopride and [C-11]RTI-121 (dopamine transporter) in rats. The BP values obtained from both models were essentially the same for all cases. In addition, the three-parameter model was insensitive to starting values, produced stable results for the other parameters (small standard errors), and converged rapidly, In conclusion, for the ligands tested the three-parameter model is a better choice, combining increased convergence rate with increased stability. (C) 1996 Academic Press, Inc.