Elevated Levels of Monocyte Activation Markers Are Associated With Subclinical Atherosclerosis in Men With and Those Without HIV Infection
Elevated Levels of Monocyte Activation Markers Are Associated With Subclinical Atherosclerosis in Men With and Those Without HIV Infection
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DOI：
10.1093/infdis/jiu594
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发表时间：
2015-04-15
影响因子：
6.4
通讯作者：
Post, Wendy S.
中科院分区：
文献类型：
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作者：
McKibben, Rebeccah A.;Margolick, Joseph B.;Post, Wendy S.
背景。人类免疫缺陷病毒（HIV）感染者的免疫激活增高可能导致动脉粥样硬化。在多中心艾滋病队列研究中，我们评估了单核细胞活化、可溶性CD163 （sCD163）和可溶性CD14 （sCD14）以及单核细胞趋化蛋白1 （CCL2）的血清学标志物与HIV感染者和非HIV感染者亚临床动脉粥样硬化的关系。我们对906名男性（566名hiv感染者和340名未感染hiv的男性）进行了非对比计算机断层扫描，其中709人同时进行了冠状动脉计算机断层扫描血管造影。每个生物标志物与冠状动脉斑块患病率、>= 50%狭窄患病率和斑块范围之间的相关性通过logistic和线性回归进行评估，调整年龄、种族、HIV血清状态和心血管危险因素。所有生物标志物的水平在艾滋病毒感染的男性中较高，其中81%的人检测不到艾滋病毒RNA，并且与较低的CD4(+) t细胞计数相关。在整个人群和艾滋病毒感染者中，较高的生物标志物水平与冠状动脉狭窄的患病率（bb0 = 50%）相关。较高的sCD163水平也与冠状动脉钙化、混合斑块和钙化斑块的患病率升高有关；较高的CCL2水平与更大程度的非钙化斑块相关。在接受治疗的hiv感染男性中，sCD163、sCD14和CCL2水平升高，且与动脉粥样硬化相关。单核细胞活化可能增加艾滋病毒感染者患心血管疾病的风险。
Background. Heightened immune activation among human immunodeficiency virus (HIV)-infected persons may contribute to atherosclerosis. We assessed associations of serologic markers of monocyte activation, soluble CD163 (sCD163) and soluble CD14 (sCD14), and monocyte chemoattractant protein 1 (CCL2) with subclinical atherosclerosis among men with and those without HIV infection in the Multicenter AIDS Cohort Study.Methods. We performed noncontrast computed tomography on 906 men (566 HIV-infected men and 340 HIV-uninfected men), 709 of whom also underwent coronary computed tomographic angiography. Associations between each biomarker and the prevalence of coronary plaque, the prevalence of stenosis of >= 50%, and the extent of plaque were assessed by logistic and linear regression, adjusting for age, race, HIV serostatus, and cardiovascular risk factors.Results. Levels of all biomarkers were higher among HIV-infected men, of whom 81% had undetectable HIV RNA, and were associated with lower CD4(+) T-cell counts. In the entire population and among HIV-infected men, higher biomarker levels were associated with a greater prevalence of coronary artery stenosis of >= 50%. Higher sCD163 levels were also associated with greater prevalences of coronary artery calcium, mixed plaque, and calcified plaque; higher CCL2 levels were associated with a greater extent of noncalcified plaque.Conclusions. sCD163, sCD14, and CCL2 levels were elevated in treated HIV-infected men and associated with atherosclerosis. Monocyte activation may increase the risk for cardiovascular disease in individuals with HIV infection.