Effects of antibodies to nerve growth factor on intrauterine development of derivatives of cranial neural crest and placode in the guinea pig.
Effects of antibodies to nerve growth factor on intrauterine development of derivatives of cranial neural crest and placode in the guinea pig.
复制标题
神经生长因子抗体对豚鼠颅神经嵴和基板衍生物宫内发育的影响。
DOI：
10.1016/0012-1606(83)90308-1
复制
发表时间：
1983
影响因子：
2.7
通讯作者：
Brandeis,L
中科院分区：
文献类型：
--
作者：
Pearson,J;Johnson,EM;Brandeis,L
在妊娠后期经胎盘暴露于母体神经生长因子抗体的胎豚鼠显示三叉神经节中感觉神经元显著耗竭。源自基板的结状神经节和螺旋神经节的感觉神经元，以及与三叉神经节的主体一样源自颅神经嵴的睫状神经节、耳神经节和蝶腭神经节的副交感运动神经元不受抗体影响。先前的研究表明，脊髓神经嵴的感觉和一些交感神经衍生物会受到影响，但起源相似的位于外周的结构则不会受到影响。胎儿的局部微环境似乎改变了来自相同原基的结构对NGF的需求。所描述的模型提供了一个有用的手段，研究营养因子抑制的影响，在自然的胎儿设置，是免费的组织培养的许多潜在的文物。比较动物结果与家族性自主神经功能障碍的病理学表明，神经生长因子功能障碍单独不，在我们目前的知识水平，充分占疾病的病因。
Fetal guinea pigs transplacentally exposed to maternal nerve growth factor antibodies in the latter part of gestation show marked depletion of sensory neurons in the trigeminal ganglion. Sensory neurons of the nodose ganglion and spiral ganglion which are derived from placodes, and parasympathetic motor neurons of the ciliary, otic, and sphenopalatine ganglia which are derived, like the bulk of the trigeminal ganglion, from cranial neural crest, are unaffected by the antibodies. Previous studies showed that sensory and some sympathetic derivatives of spinal neural crest are effected but that more peripherally located structures of similar origin are not. The local microenvironment in the fetus appears to alter the NGF requirements of structures derived from the same primordia. The model described provides a useful means of studying the effect of trophic factor inhibition in the natural fetal setting and is free of many potential artifacts of tissue culture. Comparison of the animal results with the pathology of familial dysautonomia indicates that nerve growth factor dysfunction alone does not, in our current state of knowledge, adequately account for the etiology of the disease.