Role of serum amylase and salivary cytokines in oral complications during chemoradiotherapy
Role of serum amylase and salivary cytokines in oral complications during chemoradiotherapy
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血清淀粉酶和唾液细胞因子在放化疗期间口腔并发症中的作用
DOI：
10.1111/odi.13686
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发表时间：
2020
期刊：
影响因子：
3.8
通讯作者：
Nakayama Hideki
中科院分区：
文献类型：
--
作者：
Kawahara Kenta;Hiraki Akimitsu;Arita Hidetaka;Takeshita Hisashi;Hirosue Akiyuki;Matsuoka Yuichiro;Sakata Junki;Obayashi Yuko;Nakashima Hikaru;Hirayama Mayumi;Nagata Masashi;Yoshida Ryoji;Shinohara Masanori;Nakayama Hideki
目的探讨血清淀粉酶是否能预测口腔癌放化疗患者唾液容量的恢复，并确定细胞因子（表皮生长因子、肝细胞生长因子、角化细胞生长因子）水平与口腔黏膜炎的相关性。研究对象和方法本研究纳入了84例患者，根据II期研究方案接受术前放化疗和根治性手术治疗。我们测量并分析了受刺激唾液量、血清淀粉酶和静息唾液细胞因子在基线和放化疗后1个月与口腔黏膜炎水平的相关性。结果放化疗开始时血清淀粉酶水平与放化疗后1个月刺激唾液量呈负相关（p= .03）。放化疗后静息唾液表皮生长因子明显降低（p< 0.01）。放化疗期间严重口腔黏膜炎的发生率显著增高，且与表皮生长因子和角化细胞生长因子水平呈负相关（p= 0.04,p= 0.05）。结论放化疗开始时血清淀粉酶水平可能是唾液量恢复的一个预测指标。此外，静息唾液中的表皮生长因子和角化细胞生长因子等细胞因子影响放化疗期间口腔黏膜炎的发展。
ObjectivesTo investigate whether serum amylase can predict the recovery of salivary volume and determine the correlation of the level of cytokines, including epidermal growth factor, hepatocyte growth factor and keratinocyte growth factor, with oral mucositis during chemoradiotherapy for oral cancer.Subjects and MethodsThis study included 84 patients treated with preoperative chemoradiotherapy followed by curative surgery, following a phase II study protocol. We measured and analysed the correlation of the stimulated saliva volume, serum amylase and cytokines in resting saliva at baseline and 1 month after chemoradiotherapy with oral mucositis levels.ResultsWe observed a negative correlation between the serum amylase level at the beginning of chemoradiotherapy and the stimulated saliva volume at 1 month after chemoradiotherapy (p= .03). Epidermal growth factor in resting saliva was significantly reduced after chemoradiotherapy (p< .01). The incidence of severe oral mucositis during chemoradiotherapy was significantly higher and negatively associated with the epidermal growth factor and keratinocyte growth factor levels (p= .04,p= .05).ConclusionsThe serum amylase level at the beginning of chemoradiotherapy may be a predictor of the recovery of the saliva volume. Furthermore, cytokines such as epidermal growth factor and keratinocyte growth factor in resting saliva affect the development of oral mucositis during chemoradiotherapy.