Oximetric angiosome imaging in diabetic feet.
Oximetric angiosome imaging in diabetic feet.
复制标题
糖尿病足的血氧血管体成像。
DOI：
10.1002/jmri.25220
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Mueller,MichaelJ
中科院分区：
文献类型：
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作者：
Zheng,Jie;Muccigrosso,David;Zhang,Xiaodong;An,Hongyu;Coggan,AndrewR;Adil,Bashir;Hildebolt,CharlesF;Vemuri,Chandu;Geraghty,Patrick;Hastings,MaryK;Mueller,MichaelJ
PurposeTo制定一个noncontrast血氧测定血管体成像的方法来评估骨骼肌氧合在糖尿病foot.Materials和MethodsIn四个健康和五个糖尿病患者，足部血氧测定的可行性进行了研究，使用3 T临床磁共振成像（MRI）扫描仪。受试者的足部在休息和脚趾屈曲等长运动期间进行扫描。使用基于磁化率的MRI方法测量骨骼肌的氧提取分数。将我们新开发的MR足部血氧测定血管体模型与传统血管体模型在氧提取分数分布的评估中进行了比较。结果在脚趾屈曲运动期间使用传统血管体，健康受试者内侧足部的氧提取分数增加糖尿病受试者中，（4.9 ± 3%）和（-2.7 ± 4.4%）降低（差异= 7.6%; 95%置信区间= -13.7 ± 1.4;P= 0.02）。使用血氧测定血管体，氧提取分数面积的百分比差异在0.7-1.0范围内健康受试者在休息和运动之间的氧摄取率（运动期间的预期氧摄取分数）（8 ± 4%）高于糖尿病受试者（4 ± 4%;P= 0.02）.结论本研究证明了在足趾屈曲等长运动中测量骨骼肌氧提取分数的可行性。代替评估与供应动脉相连的足部肌肉区域中的氧提取分数（传统的血管体），足部血氧测定血管体模型通过其在所有足部肌肉区域中的不同水平来评估氧提取分数，因此可能更适合于评估溃疡糖尿病足部中的局部缺血。J.磁共振Imaging 2016. J. MAGN. RESON.《影像学》2016;44：940-946。
PurposeTo develop a noncontrast oximetric angiosome imaging approach to assess skeletal muscle oxygenation in diabetic feet.Materials and MethodsIn four healthy and five subjects with diabetes, the feasibility of foot oximetry was examined using a 3T clinical magnetic resonance imaging (MRI) scanner. The subjects' feet were scanned at rest and during a toe‐flexion isometric exercise. The oxygen extraction fraction of skeletal muscle was measured using a susceptibility‐based MRI method. Our newly developed MR foot oximetric angiosome model was compared with the traditional angiosome model in the assessment of the distribution of oxygen extraction fraction.ResultsUsing the traditional angiosome during the toe‐flexion exercise, the oxygen extraction fraction in the medial foot of healthy subjects increased (4.9 ± 3%) and decreased (–2.7 ± 4.4%) in subjects with diabetes (difference = 7.6%; 95% confidence interval = –13.7 ± 1.4;P= 0.02). Using the oximetric angiosome, the percent difference in the areas of oxygen extraction fraction within the 0.7–1.0 range (expected oxygen extraction fraction during exercise) between rest and exercise was higher in healthy subjects (8 ± 4%) than in subjects with diabetes (4 ± 4%;P= 0.02).ConclusionThis study demonstrates the feasibility of measuring skeletal muscle oxygen extraction fraction in the foot muscle during a toe‐flexion isometric exercise. Instead of assessing oxygen extraction fraction in a foot muscle region linked to a supplying artery (traditional angiosome), the foot oximetric angiosome model assesses oxygen extraction fraction by its different levels in all foot muscle regions and thus may be more appropriate for assessing local ischemia in ulcerated diabetic feet. J. Magn. Reson. Imaging 2016. J. MAGN. RESON. IMAGING 2016;44:940–946.