MODULATORY EFFECTS OF SEROTONIN ON EXCITATORY AMINO-ACID RESPONSES AND SENSORY SYNAPTIC TRANSMISSION IN THE VENTROBASAL THALAMUS
MODULATORY EFFECTS OF SEROTONIN ON EXCITATORY AMINO-ACID RESPONSES AND SENSORY SYNAPTIC TRANSMISSION IN THE VENTROBASAL THALAMUS
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DOI：
10.1016/0306-4522(89)90208-x
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发表时间：
1989-01-01
期刊：
影响因子：
3.3
通讯作者：
SALT, TE
中科院分区：
文献类型：
--
作者：
EATON, SA;SALT, TE
兴奋性氨基酸受体被认为是介导感觉输入到腹侧丘脑。有证据表明脑干多巴胺能投射到腹侧基底丘脑，可能具有调节作用。5-羟色胺可能选择性地调节兴奋性氨基酸受体激动剂的反应，其对感觉突触传递的影响的可能性已在大鼠腹侧丘脑在体内进行了检查。在低电流的5-羟色胺的内泳喷射产生了显着的促进兴奋性氨基酸的反应。相反，对拟胆碱激动剂的兴奋性反应减弱。在这些情况下，突触传递伴随增强或不变。较高的5-羟色胺喷射电流逆转了这种促进作用，或抑制兴奋性氨基酸反应和突触传递。它的结论是，5-羟色胺可以调节兴奋性氨基酸的反应相对选择性和通过ventrobasal丘脑的体感信息的突触传递可能是容易受到脑干神经元的调制。
Excitatory amino acid receptors are thought to mediate sensory input to the ventrobasal thalamus. There is evidence for a brainstem serotonergic projection to the ventrobasal thalamus which may have a modulatory role. The possibility that serotonin may selectively modulate responses to excitatory amino acid receptor agonists, and its effects on sensory synaptic transmission has been examined in the rat ventrobasal thalamus in vivo. Intoophoretic ejection of serotonin at low currents produced a marked facilitation of responses to excitatory amino acids. In contrast, excitatory responses to cholinomimetic agonists were attenuated. Synaptic transmission was concomitantly enhanced or unchanged in these circumstances. Higher serotonin ejection currents reversed the facilitation, or inhibited excitatory amino acid responses and synaptic transmission. It is concluded that serotonin can modulate responses to excitatory amino acids relatively selectively and that synaptic transmission of somatosensory information through the ventrobasal thalamus may be susceptible to brainstem serotonergic modulation.