Sex-independent suppression of experimental inflammatory pain by minocycline in two mouse strains
Sex-independent suppression of experimental inflammatory pain by minocycline in two mouse strains
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DOI：
10.1016/j.neulet.2013.08.026
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发表时间：
2013-10-11
影响因子：
2.5
通讯作者：
Coelho, Marcio M.
中科院分区：
文献类型：
--
作者：
Bastos, Leandro F. S.;Prazeres, Julia D. M.;Coelho, Marcio M.
对伤害感受和抗伤害感受的性别差异以及疼痛和镇痛的性别差异的研究是一个成熟的领域。大量文献表明二甲胺四环素在实验和临床中具有抑制疼痛的作用，特别是在炎症性疼痛中。然而，据我们所知，这些影响中可能存在的质上或量上的性别差异仍有待研究。通过福尔马林实验，我们初步评估了二甲胺四环素对雌性和雄性C57BL/6小鼠的影响。福尔马林实验分为两个阶段，分别模拟伤害性疼痛（即第一阶段）和炎症性疼痛（即第二阶段）。治疗减少了雌性和雄性的第二阶段舔舐行为，在两性中效果在数量上是相似的。同样，在瑞士小鼠中也观察到相同的性别无关效应，表明存在基因型非特异性性别无关效应。虽然二甲胺四环素已经在临床试验中进行了测试，但这似乎是这种被广泛研究的药物引起的实验性疼痛抑制效应的性别差异的第一次临床前研究。二甲胺四环素诱导的抗痛觉作用中的性别独立性可能有望转化为性别独立的镇痛作用，这在治疗范式中肯定是有希望的。2013爱思唯尔爱尔兰有限公司版权所有。
The research on sex differences in nociception and antinociception as well as sex and gender differences in pain and analgesia is a maturing field. There is a vast literature showing experimental and clinical pain suppressive effects induced by minocycline, especially in inflammatory pain. However, as far as we know, possible qualitative or quantitative sex differences in those effects remained to be examined. By employing the formalin test, which has two phases of experimental pain behavior that models nociceptive pain (i.e., first phase) and inflammatory pain (i.e., second phase), we initially evaluated the effect induced by minocycline in female or male C57BL/6 mice. The treatment reduced the second phase of licking behavior in both females and males, and the effects were quantitatively similar in both sexes. Likewise, the same sex-independent effect was observed in Swiss mice, suggesting a genotype-unspecific sex-independent effect. While minocycline is already being tested in clinical trials, this appears to be the first preclinical investigation of sex differences in the experimental pain suppressive effects induced by this widely studied drug. The independence of sex in the antinociceptive effect induced by minocycline may be hopefully translated to gender-independent analgesic effects, which would be surely promising in a therapeutic paradigm. (C) 2013 Elsevier Ireland Ltd. All rights reserved.