Synthesis of 2-Azolylcycloalkanols

Synthesis of 2-Azolylcycloalkanols
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2-唑基环烷醇的合成

DOI:
10.3987/com-89-5280
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发表时间:
1990
期刊:
影响因子:
0.6
通讯作者:
Y. Makisumi
Y. Makisumi
中科院分区:
化学4区
文献类型:
--
作者:
A. Murabayashi;Y. Makisumi

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New 2-azolylcycloalkanol derivatives were synthesized stereoselectively by Grignard reaction of 2-azolylcyclohexanones, and particularly 2-azolylcycloheptanones afforded one of the diastereomers of 2-azolylcycloalkanols stereospecifically because the reagent attacked the carbonyl group from the less hindered side of the magnesium complex intermediate. These azolylcycloalkanols were tested for antifungal activities