In vivo volumetric quantitative micro-elastography of human skin.
In vivo volumetric quantitative micro-elastography of human skin.
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DOI：
10.1364/boe.8.002458
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发表时间：
2017-05
影响因子：
3.4
通讯作者：
Shaghayegh Es’haghian;Kelsey M. Kennedy;P. Gong;Qingyun Li;L. Chin;Philip Wijesinghe;D. Sampson;R. McLaughlin;B. Kennedy
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文献类型：
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作者：
Shaghayegh Es’haghian;Kelsey M. Kennedy;P. Gong;Qingyun Li;L. Chin;Philip Wijesinghe;D. Sampson;R. McLaughlin;B. Kennedy
在本文中，我们展示了人体皮肤的体内体积定量微弹性成像。通过将皮肤中测量的局部轴向应变与皮肤表面估计的局部轴向应力相结合，来估计捕获体积中每个点的弹性。这是通过利用相敏检测来测量由蒙皮和具有已知应力/应变行为的上覆柔顺透明层的压缩载荷引起的轴向位移来实现的。我们使用的成像探头可从同一方向提供光学相干断层扫描成像和压缩。我们在包含刚性内含物的组织模型上展示了我们的技术，并展示了从人类志愿者的手、手腕、前臂和腿部位置获取的体内弹性图。
In this paper, we demonstrate in vivo volumetric quantitative micro-elastography of human skin. Elasticity is estimated at each point in the captured volume by combining local axial strain measured in the skin with local axial stress estimated at the skin surface. This is achieved by utilizing phase-sensitive detection to measure axial displacements resulting from compressive loading of the skin and an overlying, compliant, transparent layer with known stress/strain behavior. We use an imaging probe head that provides optical coherence tomography imaging and compression from the same direction. We demonstrate our technique on a tissue phantom containing a rigid inclusion, and present in vivo elastograms acquired from locations on the hand, wrist, forearm and leg of human volunteers.