Sequential analysis of the effects of naltrexone on the environmental mediation of self-injurious behavior.
Sequential analysis of the effects of naltrexone on the environmental mediation of self-injurious behavior.
复制标题
纳曲酮对自伤行为环境调节作用的序列分析。
DOI：
10.1037//1064-1297.9.3.269
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Bodfish,JW
中科院分区：
文献类型：
--
作者：
Symons,FJ;Tapp,J;Wulfsberg,A;Sutton,KA;Heeth,WL;Bodfish,JW
越来越多的证据表明，生物学和环境可以介导精神发育迟滞患者的自我伤害行为（SIB）。药物治疗是否改变了自我伤害的环境介导尚不清楚。在实验性单受试者双盲安慰剂对照设计的背景下，研究了阿片类拮抗剂对自伤序贯依赖性的影响。在真实的时间内收集了4名成人受试者的SIB和工作人员互动的每日频率的直接观察数据。在4例受试者中的3例中观察到SIB率出现具有临床意义的降低（即≥ 33%）。对于所有受试者，在纳洛酮治疗期间，工作人员行为和自伤之间的序贯依赖性的大小显著大于安慰剂治疗期间。结果进行了讨论有关的行为机制的作用调节药物的自我伤害的影响。
Accumulated evidence shows that biology and the environment can mediate self-injurious behavior (SIB) in persons with mental retardation. Whether pharmacological treatment alters the environmental mediation of self-injury is unclear. Opioid antagonist effects on sequential dependencies for self-injury were studied in the context of experimental single-subject double-blind placebo-controlled designs. Direct observational data were collected for 4 adult subjects in real time on daily rate of SIB and staff interactions. Clinically significant reductions (ie,≥ 33%) in SIB rate were observed for 3 of the 4 subjects. For all subjects, the magnitude of the sequential dependency between staff behavior and self-injury was significantly greater during treatment with naltrexone than during treatment with a placebo. Results are discussed in relation to behavioral mechanisms of action regulating medication effects for self-injury.