SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability.
SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability.
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DOI：
10.3390/ijms22105391
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发表时间：
2021-05-20
影响因子：
5.6
通讯作者：
Bielinsky AK
中科院分区：
文献类型：
--
作者：
Chang YC;Oram MK;Bielinsky AK
小泛素样修饰物（SUMO）靶向的E3泛素连接酶（STUbLs）是识别SUMO化蛋白并将泛素连接到它们上的专门酶。因此，它们连接细胞SUMO化和泛素化回路。STUbL参与跨越细胞周期调节事件的多种分子过程，包括DNA修复、复制、有丝分裂和转录。它们在不受干扰的条件下运作，并应对挑战，如遗传毒性压力。这些E3泛素连接酶通过催化形成不同键的泛素链来修饰其靶底物，导致蛋白水解或非蛋白水解结果。通常，STUBL在区室化的环境中发挥作用，如核被膜或动粒，并积极帮助受损DNA和停滞的复制叉的核重新定位，以促进DNA修复或叉重新启动。此外，STUbLs与SUMO蛋白酶和去泛素化酶（DUB）位于同一附近，提供了对它们的靶标的时空控制。在这篇综述中，我们专注于STUBLs帮助维持不同物种基因组稳定性的分子机制。
Small ubiquitin-like modifier (SUMO)-targeted E3 ubiquitin ligases (STUbLs) are specialized enzymes that recognize SUMOylated proteins and attach ubiquitin to them. They therefore connect the cellular SUMOylation and ubiquitination circuits. STUbLs participate in diverse molecular processes that span cell cycle regulated events, including DNA repair, replication, mitosis, and transcription. They operate during unperturbed conditions and in response to challenges, such as genotoxic stress. These E3 ubiquitin ligases modify their target substrates by catalyzing ubiquitin chains that form different linkages, resulting in proteolytic or non-proteolytic outcomes. Often, STUbLs function in compartmentalized environments, such as the nuclear envelope or kinetochore, and actively aid in nuclear relocalization of damaged DNA and stalled replication forks to promote DNA repair or fork restart. Furthermore, STUbLs reside in the same vicinity as SUMO proteases and deubiquitinases (DUBs), providing spatiotemporal control of their targets. In this review, we focus on the molecular mechanisms by which STUbLs help to maintain genome stability across different species.
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影响因子：
62.1
作者：
Cappadocia L;Lima CD
通讯作者：
Lima CD
影响因子：
11.4
作者：
Aylon, Y;Liefshitz, B;Kupiec, M
通讯作者：
Kupiec, M
影响因子：
4.6
作者：
Barry, Kevin C.;Abed, Mona;Parkhurst, Susan M.
通讯作者：
Parkhurst, Susan M.
DOI：
10.1534/g3.113.005827
发表时间：
2013-04-09
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Tan W;Wang Z;Prelich G
通讯作者：
Prelich G
影响因子：
11.2
作者：
Briones-Orta MA;Levy L;Madsen CD;Das D;Erker Y;Sahai E;Hill CS
通讯作者：
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