Primary amyloidosis and acute leukemia associated with melphalan therapy.
Primary amyloidosis and acute leukemia associated with melphalan therapy.
复制标题
与马法兰治疗相关的原发性淀粉样变性和急性白血病。
作者：
R. Kyle;R. Pierre;E. Bayrd
淀粉样原纤维由部分免疫球蛋白轻链组成。因为轻链是由浆细胞合成的，所以用烷化剂治疗淀粉样变性患者似乎是合理的。两名患有原发性淀粉样变性并接受美法仑治疗的患者随后发展为快速致命的急性白血病。由于美法仑可能在急性白血病的发展中起重要作用，我们建议在未充分考虑相关风险的情况下，不要将烷化剂用于淀粉样变性患者的治疗，特别是在证明这些药物有益之前。
Amyloid fibrils consist in part of immunoglobulin light chains. Because light chains are synthesized by plasma cells, it seems reasonable to treat patients with amyloidosis with alkylating agents. Two patients who had primary amyloidosis and were treated with melphalan subsequently developed a rapidly fatal acute leukemia. Since melphalan may play a significant role in the development of acute leukemia, we suggest that alkylating agents not be used in the treatment of patients with amyloidosis without full consideration of risks involved, particularly until it has been proved that these drugs are beneficial.